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首页> 外文期刊>The European Journal of Neuroscience >Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro.
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Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro.

机译：白血病抑制因子是体内对外周和中枢神经系统损伤的正常炎症反应所必需的，并且在体外对巨噬细胞具有趋化性。

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摘要

The cytokine leukaemia inhibitory factor (LIF) is up-regulated in glial cells after injury to the peripheral and central nervous systems. In addition, LIF is required for the changes in neuropeptide expression that normally occur when the axons of sympathetic and sensory neurons are transected. We investigated whether LIF is also necessary for the initial inflammatory response that follows mechanical injury to the sciatic nerve and cerebral cortex of adult mice. We find that inflammatory cell infiltration into crushed sciatic nerve is significantly slower in LIF knock-out (KO) mice compared with wild-type (WT) mice. Similarly, the microglial and astroglial responses to surgical injury of the cortex are significantly slower in LIF KO mice compared with WT mice. Consistent with these in vivo results, LIF is chemotactic for peritoneal macrophages in a microchamber culture assay. Thus, LIF is a key regulator of neural injury in vivo, where it is produced by glia and can act directly on neurons, glia and inflammatory cells. We also find that the initial inflammatory response to cortical injury is diminished in interleukin (IL)-6 KO mice. Surprisingly, however, the inflammatory response in LIF-IL-6 double KO mice is very similar to that of the single KO mice, suggesting that these cytokines may act in series rather than in parallel in this response.
机译：在损伤周围和中枢神经系统后，神经胶质细胞中的细胞因子白血病抑制因子（LIF）被上调。另外，当交感神经和感觉神经元的轴突被横断时，通常发生的神经肽表达变化需要LIF。我们调查了成年小鼠坐骨神经和大脑皮层受到机械损伤后，最初的炎症反应是否也需要LIF。我们发现，与野生型（WT）小鼠相比，LIF基因敲除（KO）小鼠的炎性细胞浸润到坐骨神经压迫中明显更慢。类似地，与野生型小鼠相比，LIF KO小鼠对皮质手术损伤的小胶质细胞和星形胶质细胞反应明显慢。与这些体内结果一致，在微腔室培养测定中，LIF对腹膜巨噬细胞具有趋化作用。因此，LIF是体内神经损伤的关键调节剂，它由神经胶质细胞产生，可​​以直接作用于神经元，神经胶质细胞和炎性细胞。我们还发现，在白介素（IL）-6 KO小鼠中，对皮层损伤的初始炎症反应有所减少。然而，令人惊讶地，LIF-IL-6双KO小鼠中的炎性反应与单KO小鼠中的炎性反应非常相似，表明这些细胞因子在该反应中可能是串联作用而不是并联作用。

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