...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Dopamine D1-like receptor modulates layer- and frequency-specific short-term synaptic plasticity in rat prefrontal cortical neurons.
【24h】

Dopamine D1-like receptor modulates layer- and frequency-specific short-term synaptic plasticity in rat prefrontal cortical neurons.

机译：多巴胺D1样受体调节大鼠前额叶皮层神经元中特定于层和频率的短期突触可塑性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mesocortical dopamine (DA) input to the prefrontal cortex (PFC) is crucial for processing short-term working memory (STWM) to guide forthcoming behavior. Short-term plasticity-like post-tetanic potentiation (PTP, < 3 min) and short-term potentiation (STP, < 10 min) may underlie STWM. Using whole-cell voltage-clamp recordings, mixed glutamatergic excitatory postsynaptic currents (EPSCs) evoked by layer III or layer V stimulation (0.5 or 0.067 Hz) were recorded from layer V pyramidal neurons. With 0.5 Hz basal stimulation of layer III, brief tetani (2 x 50 Hz) induced a homosynaptic PTP (decayed: approximately 1 min). The D1-like antagonist SCH23390 (1 microm) increased the PTP amplitude and decay time without inducing changes to the tetanic response. The tetani may evoke endogenous DA release, which activates a presynaptic D1-like receptor to inhibit glutamate release to modulate PTP. With a slower (0.067 Hz) basal stimulation, the same tetani induced STP (lasting approximately 4 min, but only at 2xintensity only) that was insignificantly suppressed by SCH23390. With stimulation of layer-V-->V inputs at 0.5 Hz, layer V tetani yielded inconsisitent responses. However, at 0.067 Hz, tetani at double the intensity resulted in an STP (lasting approximately 6 min), but a long-term depression after SCH23390 application. Endogenous DA released by tetanic stimulation can interact with a D1-like receptor to induce STP in layer V-->V synapses that receive slower (0.067 Hz) frequency inputs, but suppresses PTP at layer III-->V synapses that receive higher (0.5 Hz) frequency inputs. This D1-like modulation of layer- and frequency-specific synaptic responses in the PFC may contribute to STWM processing.
机译：输入前额叶皮层（PFC）的中皮层多巴胺（DA）对于处理短期工作记忆（STWM）以指导即将发生的行为至关重要。短期可塑性样强直后增强（PTP，<3分钟）和短期增强（STP，<10分钟）可能是STWM的基础。使用全细胞电压钳记录，从V层锥体神经元记录了由III层或V层刺激（0.5或0.067 Hz）引起的混合谷氨酸能兴奋性突触后电流（EPSC）。在第III层的0.5 Hz基础刺激下，短暂的破伤风（2 x 50 Hz）诱导了同突触PTP（衰减：约1分钟）。 D1样拮抗剂SCH23390（1微米）增加了PTP幅度和衰减时间，而不会引起强直性反应的改变。破伤风可能引起内源性DA释放，这会激活突触前的D1样受体来抑制谷氨酸释放以调节PTP。在较慢的（0.067 Hz）基础刺激下，相同的破伤风引起的STP（持续约4分钟，但仅在2xintensity）仅被SCH23390显着抑制。通过以0.5 Hz刺激V-> V层输入，V形变色et产生了不稳定的响应。但是，在0.067 Hz处，邻苯二酚的强度翻倍会导致STP（持续约6分钟），但在施加SCH23390后会长期降低。强直性刺激释放的内源性DA可以与D1样受体相互作用，从而在V-> V突触层中诱导STP，后者会收到较慢的（0.067 Hz）频率输入，但会在III层-> V突触中抑制PTP，而后者会收到更高的（ 0.5 Hz）频率输入。 PFC中特定于层和频率的突触响应的这种D1类调制可能有助于STWM处理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号