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首页> 外文期刊>The European Journal of Neuroscience >Long-term potentiation of human visual evoked responses.
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Long-term potentiation of human visual evoked responses.

机译：人类视觉诱发反应的长期增强。

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摘要

Abstract Long-term potentiation (LTP) is a candidate synaptic mechanism underlying learning and memory that has been studied extensively at the cellular and molecular level in laboratory animals. To date, LTP has only been directly demonstrated in humans in isolated cortical tissue obtained from patients undergoing surgery, where it displays properties identical to those seen in non-human preparations. Inquiry into the functional significance of LTP has been hindered by the absence of a human model. Here we give the first demonstration that the rapid repetitive presentation of a visual checkerboard (a photic 'tetanus') leads to a persistent enhancement of one of the early components of the visual evoked potential in normal humans. The potentiated response is largest in the hemisphere contralateral to the tetanized visual hemifield and is limited to one component of the visual evoked response (the N1b). The selective potentiation of only the N1b component makes overall brain excitability changes unlikely and suggests that the effect is due instead to an LTP process. While LTP is known to exist in the human brain, the ability to elicit LTP from non-surgical patients will provide a human model system allowing the detailed examination of synaptic plasticity in normal subjects and may have future clinical applications in the assessment of cognitive disorders.
机译：摘要长期增强（LTP）是潜在的学习和记忆的突触机制，已经在实验动物的细胞和分子水平上进行了广泛的研究。迄今为止，LTP仅在人类中直接从接受手术的患者获得的分离的皮质组织中得到证实，其LTP具有与非人类制剂相同的特性。缺乏人类模型阻碍了对LTP功能意义的研究。在这里，我们进行第一个演示，即视觉棋盘（光影的“破伤风”）的快速重复呈现会导致正常人视觉诱发电位的早期成分之一的持续增强。增强的反应在半球形的对侧视场中最大，并且仅限于视觉诱发反应的一个组成部分（N1b）。仅N1b成分的选择性增强使得整个大脑的兴奋性变化不太可能发生，并表明该作用是LTP过程引起的。虽然已知LTP存在于人脑中，但从非手术患者中诱发LTP的能力将提供一个人体模型系统，可以对正常受试者的突触可塑性进行详细检查，并且可能在认知障碍评估中具有未来的临床应用。

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