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首页> 外文期刊>The European Journal of Neuroscience >Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs.
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Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs.

机译：纹状体快速加标的GABA能神经元的功能和分子发育及其皮质输入。

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Despite their small number, fast-spiking (FS) GABAergic interneurons play a critical role in controlling striatal output by mediating cortical feed-forward inhibition of striatal medium-sized spiny (MS) projection neurons. We have examined the functional development of FS interneurons and their cortical inputs, and the expression of three of their molecular markers, in the dorsolateral rat striatum between postnatal days (P)12-14 and 19-23, the time of major corticostriatal synaptogenesis. FS interneurons were visualized with infrared differential interference contrast (IR-DIC) optics and examined with current-clamp recording in the presence of the GABA(A) receptor antagonist bicuculline methiodide. FS interneurons displayed action potentials at relatively high frequencies in response to depolarizing current pulses by P12, but developmental changes occurred in action potential and afterhyperpolarization duration and amplitude and input resistance between P12-14 and P19-23, as well as an increase in maximum firing frequency in response to depolarizing current pulses. Maturation in electrophysiological properties was paralleled by increases in Kv3.1 and parvalbumin mRNA expression, while GAD-67 mRNA levels remained constant. Furthermore, FS interneurons in the younger age group responded to stimulation of cortical afferents with excitatory postsynaptic potentials (EPSPs) of higher amplitudes and received significantly more spontaneous depolarizing inputs than did MS neurons. Thus, FS interneurons are under frequent and continuous cortical influence by the end of the 2nd postnatal week, a time when corticostriatal synapses are sparse, suggesting that they may provide a major inhibitory influence in the striatum during the period of intense developmental maturation.
机译：尽管数量很少，但快速介导的（FS）GABA能神经元通过介导皮层前馈抑制纹状体中型棘突（MS）投射神经元在控制纹状体输出中发挥关键作用。我们检查了产后第12-14天和第19-23天（主要皮质皮质突触发生时间）之间背外侧大鼠纹状体中FS间神经元及其皮质输入的功能发育及其三个分子标记的表达。 FS中间神经元通过红外微分干涉对比（IR-DIC）光学元件进行可视化，并在存在GABA（A）受体拮抗剂双小分子甲硫脲的情况下通过电流钳记录进行检查。 FS中间神经元响应P12的去极化电流脉冲而在相对较高的频率下显示动作电位，但是动作电位和超极化持续时间，幅度和输入电阻在P12-14和P19-23之间发生了发展变化，并且最大发射量增加了响应去极化电流脉冲的频率。电生理特性的成熟与Kv3.1和小白蛋白mRNA表达的增加平行，而GAD-67 mRNA水平保持恒定。此外，在较年轻的年龄组中，FS interneurons对皮质传入神经的刺激具有更高幅度的兴奋性突触后电位（EPSPs）刺激，并且比MS神经元接受明显更多的自发去极化输入。因此，在产后第二周（皮质皮质突触稀疏的时候）之前，FS间神经受到频繁且连续的皮质影响，这表明它们可能在强烈的发育成熟期间对纹状体提供主要的抑制作用。

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