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首页> 外文期刊>The European Journal of Neuroscience >Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats.
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Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats.

机译：大鼠嗅球切除术后恐惧记忆受损，海马神经发生减少。

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摘要

It has been proposed that a decrease in adult hippocampal neurogenesis provides a biological and cellular basis for major depression. The olfactory bulbectomy (OB) in rats is widely accepted as an animal model of depression. In the present study, we investigated the effect of OB on memory formation in the memory tasks related to the hippocampal function and adult hippocampal neurogenesis. OB induced a behavioural syndrome, which was characterized by an increased activity in the open-field test and impairment in passive avoidance behaviour and contextual fear conditioning. The behavioural changes, following OB, were accompanied by a decrease in the number of proliferating cells in the dentate gyrus. Furthermore, the differentiation of the newly born cells, into mature calbindin-positive neurons, was also retarded. Stereological analysis revealed a decrease in the total granule neuron numbers within the granule cell layer of the dentate gyrus, without a significant decrease in volume of the dentate gyrus. Although a relationship between altered neurogenesis and behavioural syndrome, induced by OB, is not established yet, our results suggest that decreased neurogenesis might at least partly contribute for behavioural deficits following OB.
机译：已经提出，成年海马神经发生的减少为严重抑郁症提供了生物学和细胞基础。大鼠的嗅球切除术（OB）被广泛接受为抑郁症的动物模型。在本研究中，我们调查了OB对与海马功能和成年海马神经发生有关的记忆任务中记忆形成的影响。 OB诱发了一种行为综合症，其特征是在野外测试中活动增加以及被动回避行为和情境恐惧条件受到损害。 OB后的行为改变伴随着齿状回中增殖细胞数量的减少。此外，新生细胞分化为成熟的钙结合蛋白阳性神经元的能力也受到阻碍。立体分析显示，齿状回的颗粒细胞层内的总颗粒神经元数量减少，而齿状回的体积没有明显减少。尽管尚未确定由OB引起的神经发生改变与行为综合征之间的关系，但我们的研究结果表明神经发生减少可能至少部分地导致了OB后的行为缺陷。

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