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首页> 外文期刊>The European Journal of Neuroscience >Increases in extracellular levels of 5-HT and dopamine in the basolateral, but not in the central, nucleus of amygdala induced by aversive stimulation of the inferior colliculus.
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Increases in extracellular levels of 5-HT and dopamine in the basolateral, but not in the central, nucleus of amygdala induced by aversive stimulation of the inferior colliculus.

机译：厌食性下丘脑刺激引起的杏仁外侧基底核中5-HT和多巴胺水平升高，但杏仁核中央未升高。

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摘要

Consistent evidence has shown that dopamine release in the prefrontal cortex is increased by electrical stimulation of the inferior colliculus (IC) as unconditioned stimulus. Recent reports have also demonstrated that inactivation of the basolateral nucleus of the amygdala (BLA) with muscimol enhances the behavioural consequences of the aversive stimulation of the IC and reduces the dopamine release in the prefrontal cortex. Moreover, neurotoxic lesions of the BLA enhance whereas those of the central nucleus of the amygdala (CeA) reduce the aversiveness of the electrical stimulation of the IC. Based on these findings the present study examined the effects of the electrical stimulation of the IC on the extracellular levels of serotonin and dopamine in the BLA and CeA. To this end, rats implanted with a stimulation electrode in the IC also bore a microdialysis probe in the BLA or CeA for determination of the release of dopamine and serotonin. IC electrical stimulation at the freezing and escape thresholds increased the levels of serotonin ( approximately 70%) and dopamine ( approximately 60%) in the BLA related to the basal values. Similarly, the metabolites DOPAC and 5-HIAA increased in a parallel fashion in BLA. No significant changes could be detected in these biogenic amines and metabolites in CeA following IC aversive stimulation. These findings point to a differential role of serotonergic and dopaminergic mechanisms of the BLA and CeA in the setting up of adaptive responses to fear states generated at the inferior colliculus level.
机译：一致的证据表明，通过电刺激下丘脑（IC）作为无条件刺激可以增加前额叶皮层中的多巴胺释放。最近的报道还表明，用麝香酚灭活杏仁核（BLA）的基底外侧核可增强对IC的厌恶刺激的行为后果，并减少前额叶皮层中的多巴胺释放。此外，BLA的神经毒性损害增强，而杏仁核（CeA）的中央核损害降低了IC电刺激的厌恶性。基于这些发现，本研究检查了IC的电刺激对BLA和CeA中5-羟色胺和多巴胺细胞外水平的影响。为此，在IC中植入刺激电极的大鼠还在BLA或CeA中装有微透析探针，用于确定多巴胺和血清素的释放。 IC在冰点和逃逸阈值处的电刺激增加了BLA中与基础值相关的血清素（约70％）和多巴胺（约60％）的水平。同样，在BLA中，DOPAC和5-HIAA代谢物以平行方式增加。 IC厌恶刺激后，CeA中的这些生物胺和代谢物未发现明显变化。这些发现表明，BLA和CeA的血清素能和多巴胺能机制在建立针对下丘的水平产生的恐惧状态的适应性反应中起着不同的作用。

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