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首页> 外文期刊>The European Journal of Neuroscience >Type grouping in skeletal muscles after experimental reinnervation: another explanation.
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Type grouping in skeletal muscles after experimental reinnervation: another explanation.

机译：实验性神经支配后骨骼肌的类型分组：另一种解释。

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摘要

Abstract Type grouping signifies clustering of muscle fibres of the same metabolic type, and is a frequent finding in reinnervated muscles. To elucidate the mechanism behind it, the rat sciatic nerve was either autografted or grafted with hollow synthetic nerve grafts. Twelve weeks later the number and fibre area of the type I and type II muscle fibres in the gastrocnemic and anterior tibial muscles were determined after ATP-ase staining. The number and diameter of peroneal nerve fibres distal to the grafts were measured, and the number of Aalpha-nerve fibres was derived. Nearly all nerve and muscle morphometrical parameters changed equally in both experimental groups. However, type grouping occurred frequently only after autografting, whereas the number of nerve fibres and the number of Aalpha-nerve fibres increased in this group. Hence type grouping cannot be explained by increased intramuscular sprouting subsequent to a decrease in the number of innervating nerve fibres, as previously presumed. Regenerating axons branch along their course through the peripheral nerve. We propose that the probability of the occurrence of type grouping is related to the dispersion of sibling branches in the nerve. In the autograft, emerging branches are kept together by Schwann cell basal lamina scaffolds, in contrast to the hollow synthetic nerve grafts where the emerging branches become dispersed. Thus, in muscles reinnervated after autografting, the probability that nerve branches that arrive at a specific muscle territory are sibling branches is greater than after hollow tube grafting. Consequently, the probability that type grouping will occur is greater.
机译：摘要类型分组表示相同代谢类型的肌纤维的聚集，并且在神经支配的肌肉中经常出现。为了阐明其背后的机制，将大鼠坐骨神经自体移植或以空心合成神经移植物进行移植。十二周后，在ATP酶染色后确定胃肠道和胫前肌中I型和II型肌纤维的数量和纤维面积。测量位于移植物远端的腓神经纤维的数量和直径，并得出Aalpha神经纤维的数量。在两个实验组中，几乎所有神经和肌肉形态参数均发生了相同的变化。但是，类型分组仅在自体移植后才频繁发生，而该组中神经纤维的数量和Aalpha-神经纤维的数量增加。因此，如先前所推测的，不能通过神经支配神经纤维数量减少之后的肌肉内发芽增加来解释类型分组。再生轴突沿其过程通过周围神经分支。我们提出类型分组发生的概率与兄弟姐妹分支在神经中的分布有关。在自体移植物中，新出现的分支通过施旺细胞基底层支架保持在一起，这与空心合成神经移植物分散在其中的空心合成神经移植相反。因此，在自体移植后被神经支配的肌肉中，到达特定肌肉区域的神经分支为同级分支的概率要大于中空管移植后的概率。因此，类型分组发生的可能性更大。

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