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首页> 外文期刊>The European Journal of Neuroscience >Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery.
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Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery.

机译：矛盾的（REM）睡眠剥夺和恢复后表达Fos的胆碱能和非胆碱能脑干神经元。

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Abstract It is well accepted that populations of neurons responsible for the onset and maintenance of paradoxical sleep (PS) are restricted to the brainstem. To localize the structures involved and to reexamine the role of mesopontine cholinergic neurons, we compared the distribution of Fos- and choline acetyltransferase-labelled neurons in the brainstem of control rats, rats selectively deprived of PS for approximately 72 h and rats allowed to recover from such deprivation. Only a few cholinergic neurons from the laterodorsal (LDTg) and pedunculopontine tegmental nuclei were Fos-labelled after PS recovery. In contrast, a large number of noncholinergic Fos-labelled cells positively correlated with the percentage of time spent in PS was observed in the LDTg, sublaterodorsal, alpha and ventral gigantocellular reticular nuclei, structures known to contain neurons specifically active during PS. In addition, a large number of Fos-labelled cells were seen after PS rebound in the lateral, ventrolateral and dorsal periaqueductal grey, dorsal and lateral paragigantocellular reticular nuclei and the nucleus raphe obscurus. Interestingly, half of the cells in the latter nucleus were immunoreactive to choline acetyltransferase. In contrast to the well-accepted hypothesis, our results strongly suggest that neurons active during PS, recorded in the mesopontine cholinergic nuclei, are in the great majority noncholinergic. Our findings further demonstrate that many brainstem structures not previously identified as containing neurons active during PS contain cholinergic or noncholinergic neurons active during PS, and these structures may therefore play a key role during this state. Altogether, our results open a new avenue of research to identify the specific role of the populations of neurons revealed, their interrelations and their neurochemical identity.
机译：摘要引起悖论性睡眠（PS）发作和维持的神经元群体仅限于脑干。为了定位所涉及的结构并重新检查中桥蛋白胆碱能神经元的作用，我们比较了Fos和胆碱乙酰转移酶标记的神经元在对照组大鼠，选择性剥夺PS约72 h的大鼠和允许从中恢复的大鼠脑干中的分布。这样的剥夺。 PS恢复后，仅来自背嗅（LDTg）和足小柱被盖核的少数胆碱能神经元被Fos标记。相反，在LDTg，背外侧，α和腹侧巨细胞网状细胞核中观察到大量的非胆碱能Fos标记的细胞与在PS中所用的时间百分比呈正相关，这些结构已知包含在PS中特别活跃的神经元。此外，在PS反弹后，在外侧，腹外侧和背导水管周围的灰色，背和外侧旁巨细胞网状细胞核以及暗核中缝中可见大量的Fos标记的细胞。有趣的是，后一个细胞核中有一半的细胞对胆碱乙酰基转移酶具有免疫反应性。与公认的假设相反，我们的结果强烈表明，在中桥骨胆碱能细胞核中记录的PS期间活跃的神经元绝大多数是非胆碱能的。我们的发现进一步证明，许多先前未被鉴定为包含在PS期间活跃的神经元的脑干结构包含在PS期间活跃的胆碱能或非胆碱能神经元，因此这些结构可能在这种状态下起关键作用。总而言之，我们的研究结果开辟了一条新的研究途径，以确定所揭示的神经元群体的特定作用，它们之间的相互关系以及它们的神经化学特性。

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