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首页> 外文期刊>The European Journal of Neuroscience >Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation.
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Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation.

机译：背侧耳蜗核中的多感觉整合：对听觉和三叉神经节刺激的单位反应。

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摘要

A necessary requirement for multisensory integration is the convergence of pathways from different senses. The dorsal cochlear nucleus (DCN) receives auditory input directly via the VIIIth nerve and somatosensory input indirectly from the Vth nerve via granule cells. Multisensory integration may occur in DCN cells that receive both trigeminal and auditory nerve input, such as the fusiform cell. We investigated trigeminal system influences on guinea pig DCN cells by stimulating the trigeminal ganglion while recording spontaneous and sound-driven activity from DCN neurons. A bipolar stimulating electrode was placed into the trigeminal ganglion of anesthetized guinea pigs using stereotaxic co-ordinates. Electrical stimuli were applied as bipolar pulses (100 micros per phase) with amplitudes ranging from 10 to 100 microA. Responses from DCN units were obtained using a 16-channel, four-shank electrode. Current pulses were presented alone or preceding 100- or 200-ms broadband noise (BBN) bursts. Thirty percent of DCN units showed either excitatory, inhibitory or excitatory-inhibitory responses to trigeminal ganglion stimulation. When paired with BBN stimulation, trigeminal stimulation suppressed or facilitated the firing rate in response to BBN in 78% of units, reflecting multisensory integration. Pulses preceding the acoustic stimuli by as much as 95 ms were able to alter responses to BBN. Bimodal suppression may play a role in attenuating body-generated sounds, such as vocalization or respiration, whereas bimodal enhancement may serve to direct attention in low signal-to-noise environments.
机译：多感官整合的必要要求是来自不同感官的途径的融合。背侧耳蜗核（DCN）直接通过第VIII条神经接收听觉输入，并通过颗粒细胞间接地从Vth神经接收体感输入。多感觉整合可能发生在接受三叉神经和听觉神经输入的DCN细胞中，例如梭形细胞。我们通过刺激三叉神经节同时记录来自DCN神经元的自发和声音驱动活动，研究了三叉神经系统对豚鼠DCN细胞的影响。使用立体定向坐标将双极刺激电极放置在麻醉的豚鼠的三叉神经节中。电刺激以双极性脉冲（每相100微米）的形式施加，幅度在10到100 microA之间。 DCN单元的响应是使用16通道四柄电极获得的。当前脉冲单独出现或在100或200毫秒宽带噪声（BBN）突发之前出现。 30％的DCN单元显示出对三叉神经节刺激的兴奋性，抑制性或兴奋性抑制性反应。当与BBN刺激搭配使用时，三叉神经刺激在78％的单位中抑制或促进了对BBN的激发速度，反映了多感觉整合。声刺激之前长达95毫秒的脉冲能够改变对BBN的响应。双峰抑制可能在减弱身体产生的声音（例如发声或呼吸）中起作用，而双峰增强可能在低信噪比的环境中引导注意力。

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