Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant.

Al Fayez M; Russell D; Wayne Davies R; Shiels PG; Baker PJ; Payne AP

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Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant.

机译：AS / AGU大鼠（一种蛋白激酶C-γ突变体）的中脑沟纹和纹状体缺乏。

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The AS/AGU rat carries a recessive mutation (agu) in the gene coding for the gamma isoform of protein kinase C. The rat is characterized by disordered locomotion and progressive dysfunction of the nigrostriatal dopaminergic (DA) system. This dysfunction begins with a failure to release DA within the striatum and culminates in cell loss within the substantia nigra pars compacta. The present study examines another midbrain aminergic system with input to the basal ganglia, the serotonergic (5-HT) raphe-striatal system originating in the dorsal raphe nucleus. By 3 months after birth, there is a very substantial reduction in the extracellular levels of 5-HT in the dorsal caudate-putamen of the mutants compared with controls (c. 70%). This is accompanied by a proportional increase in the levels of the 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA). At a later age, there are reductions in whole tissue 5-HT (and increases in 5-HIAA) in both the striatum and the region containing the dorsal raphe nucleus, as well as numbers of 5-HT-immunoreactive cells in the dorsal raphe nucleus. The median raphe appears to be unaffected. The results are seen in terms of an initial dysfunction in transmitter release leading to cell death, perhaps through the formation of free radicals or neurotoxins.

机译：AS / AGU大鼠在编码蛋白激酶C的γ亚型的基因中带有隐性突变（agu）。该大鼠的特征是黑质纹状体多巴胺能（DA）系统的运动异常和进行性功能障碍。这种功能障碍以无法在纹状体内释放DA开始，并最终导致黑质致密部细胞丢失。本研究检查了另一种向基底神经节输入的中脑胺能系统，即源自背沟核的血清素能（5-HT）沟纹-纹状体系统。出生后3个月，与对照组相比，突变体背尾状丘脑中5-HT的细胞外水平显着降低（约70％）。这伴随着5-HT代谢物5-羟基吲哚乙酸（5-HIAA）水平的成比例增加。在较晚的年龄，纹状体和含有背缝核的区域的全组织5-HT减少（而5-HIAA增加），以及背缝中5-HT免疫反应性细胞的数量核。中缝线似乎不受影响。从可能导致自由基或神经毒素形成的导致细胞死亡的递质释放的最初功能障碍来看，可以看到结果。

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来源
《The European Journal of Neuroscience》 |2005年第11期|共7页
作者
Al Fayez M; Russell D; Wayne Davies R; Shiels PG; Baker PJ; Payne AP;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Neostriatum; Protein Kinase C; Raphe Nuclei; 新纹状体; 蛋白激酶C; 中缝核;

机译：Neostriatum;Protein Kinase C;Raphe Nuclei;新纹状体;蛋白激酶C;中缝核;

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1. Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant. [J] . Al Fayez M, Russell D, Wayne Davies R, The European Journal of Neuroscience . 2005,第11期

机译：AS / AGU大鼠（一种蛋白激酶C-γ突变体）的中脑沟纹和纹状体缺乏。
2. Protein Kinase C-gamma and Calcium/Calmodulin-Dependent Protein Kinase II-alpha Are Persistently Translocated to Cell Membranes of the Rat Brain During and After Middle Cerebral Artery Occlusion. [J] . Matsumoto S, Shamloo M, Matsumoto E, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2004,第1期

机译：蛋白激酶C-γ和钙/钙调蛋白依赖性蛋白激酶II-alpha在大脑中动脉闭塞过程中和之后持续转移到大鼠脑的细胞膜。
3. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. [J] . C M Pleiman, M R Clark, L K Gauen, Molecular and Cellular Biology . 1993,第9期

机译：Src家族蛋白酪氨酸激酶p55blk，p59fyn和p56lyn上与效应分子磷脂酶C-γ2，微管相关的蛋白激酶，GTPase激活蛋白和磷脂酰肌醇3激酶相互作用的位点图谱。
4. Changes in protein phosphorylation and abundance in a drought sensitive rice MAP Kinase mutant. [C] . Sophie Alvarez, Ellen Marsh, Jing Ning, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：干旱敏感稻瘟病激酶突变体蛋白质磷酸化和丰度的变化。
5. Development of a cellular mimetic protein kinase assay and a novel methodology for determining the mode of inhibition for multisubstrate enzymes, and rational design and synthesis of protein kinase inhibitors. [D] . Choi, Sun. 1999

机译：细胞模拟蛋白激酶测定法的发展和确定多底物酶抑制模式的新方法，以及蛋白激酶抑制剂的合理设计和合成。
6. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. [O] . C M Pleiman, M R Clark, L K Gauen, 1985

机译：Src家族蛋白酪氨酸激酶p55blk，p59fyn和p56lyn上与效应分子磷脂酶C-γ2，微管相关蛋白激酶，GTPase激活蛋白和磷脂酰肌醇3-激酶相互作用的位点图谱。
7. Protein Kinase C-gamma and Calcium/Calmodulin-Dependent Protein Kinase II-alpha Are Persistently Translocated to Cell Membranes of the Rat Brain During and After Middle Cerebral Artery Occlusion. [O] . Matsumoto, Shohei, Shamloo, Mehrdad, Matsumoto, Eriko, 2004

机译：在大脑中动脉闭塞期间和之后，蛋白激酶C-γ和钙/钙调蛋白依赖性蛋白激酶II-α持续易位至大鼠脑细胞膜。

Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant.

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