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首页> 外文期刊>The European Journal of Neuroscience >Selective effects of partial striatal 6-OHDA lesions on information processing in the rat.
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Selective effects of partial striatal 6-OHDA lesions on information processing in the rat.

机译：部分纹状体6-OHDA损伤对大鼠信息处理的选择性作用。

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Abstract The present study was aimed at characterizing the cognitive deficits caused by the degeneration of nigrostriatal dopamine (DA) pathways by using the additive factor logic [Sternberg, S. (1969) Acta Psychol., 30, 276-315], a powerful reaction time (RT) method developed in humans and recently introduced in the rat [Courtiere, A., Hardouin, J., Hasbroucq, T., Possamai, C.-A. & Vidal, F. (2000) Behav. Process., 50, 113-121]. Long-Evans rats were trained to respond to left or right (lateral) visual cues in a choice RT task. Two task factors, signal intensity and force requirement, were manipulated. Partial bilateral 6-OHDA lesions of DA nerve terminals in the striatum were then performed and their effects tested for up to 7 weeks following surgery. Reaction time was lengthened from the 2nd to the 4th week postlesion. This alteration was independent of force requirement, thereby suggesting that the related motor processes were not influenced by the DA depletion. During the 2nd week postlesion, the RT increase was accompanied by a disappearance of the effect of signal intensity, showing that the lesion altered stimulus-related processes. From the 3rd week the signal intensity effect was re-established although RT was still increased, indicating that the stimulus-related processes had recovered while other central processes were still impaired. From the 5th week after surgery, the lesioned animals had completely recovered from the RT deficits induced by the lesion. These results point at the involvement of striatal DA in sensory and central information processes.
机译：摘要本研究旨在通过使用加性因子逻辑[Sternberg，S.（1969）Acta Psychol。，30，276-315]来表征由黑质纹状体多巴胺（DA）途径退化引起的认知缺陷。时间（RT）方法在人类中得到发展，最近又在大鼠中使用[Courtiere，A.，Hardouin，J.，Hasbroucq，T.，Possamai，C.-A。 ＆Vidal，F.（2000年）《行为》。 ，50，113-121]。训练Long-Evans大鼠在选择RT任务中对左或右（外侧）视觉提示做出反应。操纵了两个任务因素，即信号强度和力量要求。然后进行纹状体DA神经末梢的局部双侧6-OHDA损伤，并在术后7周内测试其效果。反应时间从病变后的第二周延长至第四周。这种变化与力的要求无关，因此表明相关的运动过程不受DA消耗的影响。在病变后第二周，RT升高伴随着信号强度效应的消失，表明病变改变了与刺激相关的过程。从第3周起，尽管RT仍然增加，但信号强度效应得以重新建立，这表明与刺激有关的过程已经恢复，而其他中央过程仍然受到损害。从手术后第5周起，患病动物已完全从由病变引起的RT缺乏中恢复。这些结果表明纹状体DA参与了感觉和中央信息过程。

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