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首页> 外文期刊>The European Journal of Neuroscience >Synaptic contacts between an identified type of ON cone bipolar cell and ganglion cells in the mouse retina.
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Synaptic contacts between an identified type of ON cone bipolar cell and ganglion cells in the mouse retina.

机译：小鼠视网膜中已识别类型的ON锥体双极细胞和神经节细胞之间的突触接触。

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Abstract We surveyed the potential contacts between an identified type of bipolar cell and retinal ganglion cells in the mouse. By crossing two existing mouse strains (line 357 and line GFP-M), we created a double transgenic strain in which GFP is expressed by all members of a single type of ON cone bipolar cell and a sparse, mixed population of retinal ganglion cells. The GFP-expressing bipolar cells appear to be those termed CB4a of Pignatelli & Strettoi [(2004) J. Comp. Neurol., 476, 254-266] and type 7 of Ghosh et al. [(2004) J. Comp. Neurol., 469, 70-82 and J. Comp. Neurol., 476, 202-203]. The labelled ganglion cells include examples of most or all types of ganglion cells present in the mouse. By studying the juxtaposition of their processes in three dimensions, we could learn which ganglion cell types are potential synaptic targets of the line 357 bipolar cell. Of 12 ganglion cell types observed, 10 types could be definitively ruled out as major synaptic targets of the line 357 bipolar cells. Onetype of monostratified ganglion cell and one bistratified cell tightly cofasciculate with axon terminals of the line 357 bipolar cells. Double labelling for kinesin II demonstrates colocalization of bipolar cell ribbons at the sites of contact between these two types of ganglion cell and the line 357 bipolar cells.
机译：摘要我们调查了小鼠中已识别类型的双极细胞和视网膜神经节细胞之间的潜在接触。通过杂交两个现有的小鼠品系（品系357和品系GFP-M），我们创建了一个双转基因品系，其中GFP由单一类型的ON锥双极细胞和稀疏，混合的视网膜神经节细胞群体的所有成员表达。表达GFP的双极细胞似乎是被称为Pignatelli＆Strettoi的CB4a的细胞[（2004）J.Comp。 Neurol。，476，254-266]和Ghosh等人的7型。 [（2004）J. Comp。 Neurol。，469，70-82和J. Comp。 Neurol。，476，202-203]。标记的神经节细胞包括小鼠中存在的大多数或所有类型的神经节细胞的实例。通过在三个维度上研究其过程的并置，我们可以了解哪些神经节细胞类型是357双极细胞系的潜在突触靶标。在观察到的12种神经节细胞类型中，可以确定地排除10种作为357个双极细胞系的主要突触靶标。单层神经节细胞的一种类型和一个双层细胞与357行双极细胞的轴突末端紧密共聚焦。驱动蛋白II的双重标记表明双极细胞带在这两种类型的神经节细胞和357行双极细胞之间的接触部位共定位。

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