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首页> 外文期刊>The European Journal of Neuroscience >Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease.
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Stimulation through electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson's disease.

机译：通过植入丘脑下核附近的电极进行刺激，可以激活帕金森氏病患者大脑皮质运动区的投射。

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摘要

Abstract High-frequency electrical stimulation through electrodes implanted in the subthalamic nucleus (STN) has been shown to reduce significantly the cardinal symptoms of Parkinson's disease (PD). Despite the success of this treatment, the mechanisms of action of stimulation are poorly understood. To elucidate further the mechanisms of action of deep brain stimulation and its effects on cortical activity, we recorded electroencephalographic potentials from 61 scalp-surface electrodes during low-frequency (5-10 Hz) bipolar stimulation in 11 patients with advanced PD (14 implanted electrodes were tested). In all electrodes tested, stimulation through at least one of the four contacts produced a medium-latency waveform with an average onset of 14 +/- 3 ms and peak at 23 +/- 4 ms. This potential typically increased in magnitude across contacts from ventral to dorsal. Within-subject comparisons of median nerve somatosensory evoked potentials demonstrated that the generator of the medium-latency potential was within the primary sensorimotor cortex or lateral premotor cortex ipsilateral to stimulation. The timing and topography of this potential were consistent with indirect activation of the cortex by excitation of pallido-thalamic axons that traverse the dorsal aspect of the STN. The potential evoked by stimulation through the contact used for optimal clinical effect was highly variable across electrodes and frequently different from the medium-latency potential described above, suggesting that the neuronal elements mediating the medium-latency potential were different from those that mediate the clinical effects.
机译：摘要研究表明，通过植入丘脑底核（STN）的电极进行高频电刺激可以显着减轻帕金森氏病（PD）的基本症状。尽管该治疗成功，但对刺激作用的机理了解甚少。为了进一步阐明深部脑刺激的作用机制及其对皮层活动的影响，我们记录了11名晚期PD患者（14个植入电极）在低频（5-10 Hz）双极刺激期间从61头皮表面电极记录的脑电图电位经过测试）。在所有测试的电极中，通过四个触点中至少一个的刺激产生中等潜伏波形，平均起效时间为14 +/- 3毫秒，峰值为23 +/- 4毫秒。从腹侧到背侧的接触，该电位通常会增加。受试者中位神经躯体感觉诱发电位的比较表明，中等潜伏电位的产生者在与刺激同侧的主要感觉运动皮层或外侧运动前皮层内。这种潜力的时机和地形与通过穿越STN背侧的丘脑-丘脑轴突的激发而间接激活皮层相一致。通过接触所产生的最佳临床效果的接触所激发的电位在电极之间变化很大，并且经常不同于上述的中潜伏电位，这表明介导中潜伏电位的神经元与介导临床效应的神经元不同。 。

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