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首页> 外文期刊>The European Journal of Neuroscience >Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation.
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Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation.

机译：非适应性应激对神经源性血浆外渗的影响中的性二态性。

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摘要

The sympathoadrenal axis contributes to the sexual dimorphism of the inflammatory response. As stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory disease, we evaluated whether stress exerts a sexually dimorphic effect on a major component of the inflammatory response, plasma extravasation. We evaluated the effect of a nonhabituating stress, repeated intermittent sound (30 min/day for 4 days), on neurogenic synovial plasma extravasation, induced by bradykinin in the rat knee joint. Sound stress profoundly inhibited bradykinin-induced plasma extravasation in male rats, but profoundly enhanced it in female rats. These effects took 24 h to fully develop after the last exposure to stress. In gonadectomized males, bradykinin-induced plasma extravasation was lower than intact males, and sound stress now enhanced it, i.e. gonadectomized males were phenotypically like intact females. In gonadectomized females, bradykinin-induced plasma extravasation was greater than in intact adult females, and sound stress still enhanced it. Adrenal enucleation significantly attenuated the effect of sound stress on bradykinin-induced plasma extravasation in both male and female rats. We tested the hypothesis that these effects of sound stress were due to sustained enhanced plasma levels of stress hormones. Corticosterone and epinephrine, only when administered in combination, over five days, produced a qualitatively similar effect as sound stress, i.e. bradykinin-induced plasma extravasation was significantly decreased in males and increased in females. These findings suggest that a combined effect of the hypothalamic-pituitary adrenal and sympathoadrenal stress axes are responsible for the marked sexual dimorphism in the effect of stress on the inflammatory response.
机译：交感肾上腺轴有助于炎症反应的性二态性。由于压力既激活了交感肾上腺轴，又深刻地影响了炎症和炎症性疾病，因此我们评估了压力是否对炎症反应的主要成分血浆外渗产生性二态作用。我们评估了非适应性压力，反复断续的声音（30分钟/天，共4天）对大鼠膝关节缓激肽诱导的神经源性滑膜血浆外渗的影响。声应力深刻地抑制了缓激肽诱导的雄性大鼠血浆外渗，但深刻地增强了雌性大鼠的血浆外渗。在最后一次暴露于压力后，这些作用需要24小时才能完全发展。在淋巴结清扫术的男性中，缓激肽诱导的血浆外渗比完整的雄性要低，并且现在声音压力增强了这种情况，即，经淋巴结清扫的男性在表型上像完整的雌性。在经过性腺切除术的女性中，缓激肽诱导的血浆外渗大于完整成年女性的血浆外渗，声压仍然增强了这种情况。肾上腺去核显着减弱了声压对缓激肽诱导的雄性和雌性大鼠血浆外渗的影响。我们检验了以下假设：声音压力的这些作用是由于压力激素的血浆水平持续升高所致。皮质酮和肾上腺素仅在五天之内联合使用时，会产生与声音压力相似的定性作用，即，缓激肽诱导的血浆外渗在男性中明显减少，在女性中增加。这些发现表明，下丘脑-垂体肾上腺和交感肾上腺应激轴的联合作用是应激对炎症反应的影响中明显的性二态性的原因。

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