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首页> 外文期刊>The European Journal of Neuroscience >Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II.
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Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II.

机译：在重新整合过程中通过真实生活事件来增强记忆力：通过脑血管紧张素II导致缺水的结果。

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A considerable body of evidence reveals that consolidated memories, recalled by a reminder, enter into a new vulnerability phase during which they are susceptible to disruption again. Consistently, reconsolidation was shown by the amnesic effects induced by administration of consolidation blockers after memory labilization. To shed light on the functional value of reconsolidation, we explored whether an endogenous process activated during a concurrent real-life experience improved this memory phase. Reconsolidation of long-term contextual memory has been well documented in the crab Chasmagnathus. Previously we showed that angiotensin II facilitates memory consolidation. Moreover, water deprivation increases brain angiotensin and improves memory consolidation and retrieval through angiotensin II receptors. Here, we tested whether concurrent water deprivation improves reconsolidation via endogenous angiotensin and therefore strengthens memory. We show that memory reconsolidation, induced by training context re-exposure, is facilitated by a concurrent episode of water deprivation, which induces a raise in endogenous brain angiotensin II. Positive modulation is expressed by full memory retention, despite a weak training, 24 or 72 but not 4 h after memory reactivation. This is the first evidence that memory can be positively modulated during reconsolidation through an identified endogenous process triggered during a real-life episode. We propose that the functional value for reconsolidation would be to make possible a change in memory strength by the influence of a concurrent experience. Reconsolidation improvement would lead to memory re-evaluation, not by altering memory content but by modifying the behaviour as an outcome of changing the hierarchy of the memories that control it.
机译：大量证据表明，回忆提醒的合并记忆进入了一个新的漏洞阶段，在此期间，它们很容易再次受到破坏。一致地，通过记忆化后给予固结阻滞剂引起的记忆删除效应显示出了固结。为了阐明重新整合的功能价值，我们探讨了在并发现实生活中激活的内源性过程是否可以改善此记忆阶段。螃蟹Chasmagnathus充分记录了长期的上下文记忆。先前我们显示血管紧张素II有助于记忆整合。此外，缺水会增加大脑血管紧张素的含量，并通过血管紧张素II受体改善记忆巩固和恢复。在这里，我们测试了并发缺水是否通过内源性血管紧张素改善了再巩固，从而增强了记忆力。我们显示，由训练情境的再暴露诱导的记忆再巩固是由水缺乏的同时发作而促进的，这会引起内源性脑血管紧张素II的升高。记忆力恢复后24小时或72小时，尽管训练较弱，但通过完全记忆保留来表达正调制。这是第一个证据，表明在重新整合过程中，可以通过在现实生活中触发的已识别的内源性过程来积极调节记忆。我们建议重新整合的功能价值是通过并发体验的影响来使内存强度发生变化。重新整合的改进将导致内存重新评估，而不是通过更改内存内容，而是通过更改行为来改变内存，从而控制内存，从而重新评估内存。

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