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首页> 外文期刊>The European Journal of Neuroscience >Galanin-neuropeptide Y (NPY) interactions in central cardiovascular control: involvement of the NPY Y receptor subtype.
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Galanin-neuropeptide Y (NPY) interactions in central cardiovascular control: involvement of the NPY Y receptor subtype.

机译：中央心血管控制中的甘丙肽-神经肽Y（NPY）相互作用：NPY Y受体亚型的参与。

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摘要

The interactions between neuropeptide Y (NPY), specifically through NPY Y(1) and Y(2) receptor subtypes, and galanin [GAL(1-29)] have been analysed at the cardiovascular level. The cardiovascular effects of intracisternal coinjections of GAL(1-29) with NPY or NPY Y(1) or Y(2) agonists, as well as quantitative receptor autoradiography of the binding characteristics of NPY Y(1) and Y(2) receptor subtypes in the nucleus of the solitary tract (NTS), in the presence or absence of GAL(1-29), have been investigated. The effects of coinjections of GAL(1-29) and the NPY Y(1) agonist on the expression of c-FOS immunoreactivity in the NTS were also studied. The coinjection of NPY with GAL(1-29) induced a significant vasopressor and tachycardic action with a maximum 40% increase (P < 0.001). The coinjection of the NPY Y(1) agonist and GAL(1-29) induced a similar increase in mean arterial pressure and heart rate as did NPY plus GAL(1-29), actions that were not observed with the NPY Y(2) agonist plus GAL(1-29). GAL(1-29), 3 nm, significantly and substantially (by approximately 40%) decreased NPY Y(1) agonist binding in the NTS. This effect was significantly blocked (P < 0.01) in the presence of the specific galanin antagonist M35. The NPY Y(2) agonist binding was not modified in the presence of GAL(1-29). At the c-FOS level, the coinjection of NPY Y(1) and GAL(1-29) significantly reduced the c-FOS-immunoreactive response induced by either of the two peptides. The present findings suggest the existence of a modulatory antagonistic effect of GAL(1-29) mediated via galanin receptors on the NPY Y(1) receptor subtype and its signalling within the NTS.
机译：已经在心血管水平上分析了神经肽Y（NPY），特别是通过NPY Y（1）和Y（2）受体亚型与甘丙肽[GAL（1-29）]之间的相互作用。 GAL（1-29）与NPY或NPY Y（1）或Y（2）激动剂的脑池内共同注射对心血管的影响以及NPY Y（1）和Y（2）受体结合特征的定量放射自显影在存在或不存在GAL（1-29）的情况下，研究了孤立道（NTS）核中的亚型。还研究了GAL（1-29）和NPY Y（1）激动剂共同注射对NTS中c-FOS免疫反应性表达的影响。 NPY与GAL（1-29）的共注射诱导了显着的血管升压和心动过速作用，最大增加了40％（P <0.001）。 NPY Y（1）激动剂和GAL（1-29）的共同注射引起的平均动脉压和心率增加与NPY + GAL（1-29）相似，而NPY Y（2）并未观察到这种作用）激动剂加GAL（1-29）。 GAL（1-29），3 nm，显着且实质上（降低约40％）降低了NTS中的NPY Y（1）激动剂结合。在特定甘丙肽拮抗剂M35的存在下，该作用被显着阻断（P <0.01）。在GAL（1-29）的存在下，NPY Y（2）激动剂结合没有被修饰。在c-FOS水平上，NPY Y（1）和GAL（1-29）的共同注射显着降低了由两种肽之一诱导的c-FOS免疫反应。本发现表明存在通过甘丙肽受体介导的GAL（1-29）对NPY Y（1）受体亚型的调节拮抗作用及其在NTS内的信号传导。

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