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首页> 外文期刊>The European Journal of Neuroscience >Long-term depression and associativity in rat primary motor cortex following thalamic stimulation.
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Long-term depression and associativity in rat primary motor cortex following thalamic stimulation.

机译：丘脑刺激后大鼠初级运动皮层的长期抑郁和联想。

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摘要

Associativity is an attractive property of LTP in terms of its possible mechanism as a model for memory storage. In this study, we compare the effects of homosynaptic vs. associative stimulation on the induction of LTP and LTD in the neocortex of freely behaving rats. Using a callosal input to the motor cortex as a 'strong' input (one that potentiates reliably following homosynaptic stimulation), we paired activity of this pathway with a 'weak' thalamocortical pathway (one that does not potentiate when stimulated homosynaptically). Surprisingly, homosynaptic HFS caused a lasting depression of the field EPSP in the thalamocortical pathway. Analysis of this effect revealed that it was largely polysynaptic. Associative HFS (HFS applied to both pathways) not only failed to induce an LTP effect in the thalamocortical pathway, it increased the magnitude of the depression. Associative HFS did, however, facilitate LTP induction in the 'strong' callosal pathway. When comparing the effects of homosynaptic and associative LTD induction (HFS on one pathway anticorrelated with LFS on the other), we found that both protocols induced a similar magnitude of depression. These results show that HFS applied to the thalamocortical pathway causes a depression and this depression is enhanced, not reversed, by associative pairing with a strong input.
机译：就其作为内存存储模型的可能机制而言，关联性是LTP的一项吸引人的特性。在这项研究中，我们比较了同性突触和联想刺激对行为自由大鼠新皮层中LTP和LTD诱导的影响。使用运动皮质的tex输入作为“强”输入（在同型突触刺激后可靠地增强的输入），我们将该途径的活性与“弱”的丘脑皮质通路（在同型突触刺激时不增强的）配对。出乎意料的是，同突触HFS导致丘脑皮质通路中的EPSP场持续下降。对这种作用的分析表明，它主要是多突触的。联想性HFS（同时应用于两种途径的HFS）不仅未能在丘脑皮质途径中诱导LTP效应，而且还增加了抑郁症的程度。然而，联合的HFS确实促进了“强” call途径中的LTP诱导。当比较同源突触和联想LTD诱导（一种途径的HFS与另一种途径的LFS反相关）的效果时，我们发现两种方案均诱发了相似程度的抑郁。这些结果表明，应用于丘脑皮质途径的HFS引起抑郁，并且这种抑郁通过联想配对和强输入而增强而不是逆转。

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