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首页> 外文期刊>The European Journal of Neuroscience >Chemosensory and steroid-responsive regions of the medial amygdala regulate distinct aspects of opposite-sex odor preference in male Syrian hamsters.
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Chemosensory and steroid-responsive regions of the medial amygdala regulate distinct aspects of opposite-sex odor preference in male Syrian hamsters.

机译：杏仁核的化学感应和类固醇反应区域调节雄性叙利亚仓鼠对异性气味偏好的不同方面。

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In rodent species, such as the Syrian hamster, the expression of sexual preference requires neural integration of social chemosensory signals and steroid hormone cues. Although anatomical data suggest that separate pathways within the nervous system process these two signals, the functional significance of this separation is not well understood. Specifically, within the medial amygdala, the anterior region (MEa) receives input from the olfactory bulbs and other chemosensory areas, whereas the posterodorsal region (MEpd) contains a dense population of steroid receptors and receives less substantial chemosensory input. Consequently, the MEa may subserve a primarily discriminative function, whereas the MEpd may mediate the permissive effects of sex steroids on sexual preference. To test these hypotheses, we measured preference and attraction to female and male odors in males with lesions of either the MEa or MEpd. In Experiment 1, lesions of either region eliminated opposite-sex odor preferences. Importantly, MEpd-lesioned males displayed decreased attraction toward female odors, suggesting decreased sexual motivation. In contrast, MEa-lesioned males displayed high levels of investigation of both male and female odors, suggesting an inability to categorize the relevance of the odor stimuli. In Experiment 2, we verified that both MEa- and MEpd-lesioned males could discriminate between female and male odors, thereby eliminating the possibility that the observed lack of preference reflected a sensory deficit. Taken together, these results suggest that both the MEa and MEpd are critical for the expression of opposite-sex odor preference, although they appear to mediate distinct aspects of this behavior.
机译：在啮齿类动物中，例如叙利亚仓鼠，要表达性偏好，需要社交化学感应信号和类固醇激素提示的神经整合。尽管解剖学数据表明神经系统内的分离途径处理了这两个信号，但这种分离的功能意义尚未得到很好的理解。具体而言，在杏仁核内侧，前区（MEa）接收来自嗅球和其他化学感觉区域的输入，而后嗅区（MEpd）包含密集的类固醇受体，并接收较少的化学感觉输入。因此，MEa可能具有主要的判别功能，而MEpd可能介导性类固醇对性偏好的允许作用。为了检验这些假设，我们测量了患有MEa或MEpd病变的男性对男性和女性气味的偏好和吸引力。在实验1中，任一区域的病变都消除了对异性的气味偏好。重要的是，患有MEpd的男性对女性气味的吸引力降低，表明性动机降低。相比之下，MEa病变的雄性对雄性和雌性气味的调查显示出很高的水平，这表明无法对气味刺激的相关性进行分类。在实验2中，我们验证了MEa和MEpd病变的雄性都可以区分雌性和雄性气味，从而消除了观察到的缺乏偏好反映感官缺陷的可能性。两者合计，这些结果表明，尽管MEa和MEpd似乎介导了这种行为的不同方面，但它们对于表达异性气味偏好至关重要。

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