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首页> 外文期刊>The European Journal of Neuroscience >Substantia nigra pars compacta is critical to both the acquisition and expression of learned orienting of rats.
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Substantia nigra pars compacta is critical to both the acquisition and expression of learned orienting of rats.

机译：黑质致密性对大鼠学习定向的获取和表达都至关重要。

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Novel events produce characteristic orienting responses (ORs), which typically habituate rapidly with repeated stimulus presentation. However, they may re-emerge if those stimuli become predictors of biologically significant events. This acquisition of conditioned ORs may reflect a broader range of enhancements in top-down attentional processing of cues that predict important consequences. Previous research from this laboratory showed that a neural circuit that includes the amygdala central nucleus (CeA), substantia nigra pars compacta (SNc) and dorsolateral striatum (DLS) is essential for the learning and expression of one example of conditioned orienting, the rearing of rats to visual stimuli paired with food. Other studies showed that the CeA is critical to the acquisition of these conditioned ORs, but not their expression, and that normal DLS function is required for the expression of previously acquired conditioned ORs, but not for learning itself. The experiments reported here considered the roles of the SNc in conditioned orienting by examining the effects of transient inactivation of the SNc during the acquisition of new associations and during the expression of previous learning. SNc function was critical to both the acquisition and expression of conditioned ORs but not to the display of unconditioned ORs or the learning and expression of conditioned responses directed to the food source. Together with our previous findings, these results suggest that the SNc is trained by the CeA during learning and maintains acquired information so that it may modulate DLS sensory-motor function at the time of action.
机译：新颖的事件会产生特征性的定向反应（OR），通常会在重复刺激刺激后迅速适应。但是，如果这些刺激成为生物学上重要事件的预测因子，它们可能会重新出现。条件OR的这种获取可能反映了自上而下的注意力预测提示重要结果提示处理中的广泛增强。该实验室先前的研究表明，包括杏仁核中央核（CeA），黑质致密部（SNc）和背外侧纹状体（DLS）在内的神经回路对于学习和表达条件性定向的一个例子是必不可少的。大鼠以视觉刺激与食物配对。其他研究表明，CeA对获得这些条件性OR至关重要，但对它们的表达并不重要，并且以前表达的条件性OR的表达需要正常的DLS功能，而不是学习本身。此处报道的实验通过检查SNc在获得新关联时和先前学习过程中瞬时失活的影响，来考虑SNc在条件定向中的作用。 SNc功能对于条件性OR的获取和表达都至关重要，但对非条件性OR的展示或针对食物源的条件性反应的学习和表达都不重要。结合我们先前的发现，这些结果表明SNc在学习过程中受到CeA的训练并保持获得的信息，因此在动作时它可以调节DLS感觉运动功能。

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