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首页> 外文期刊>The European Journal of Neuroscience >Evidence for a direct, short latency projection from the dorsal cochlear nucleus to the auditory thalamus in the guinea pig.
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Evidence for a direct, short latency projection from the dorsal cochlear nucleus to the auditory thalamus in the guinea pig.

机译：从豚鼠的耳蜗背侧核到听觉丘脑的直接，短时延投影的证据。

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摘要

The auditory thalamus (medial geniculate body, MGB) receives its main ascending input from the inferior colliculus (IC), which was considered to be an obligatory relay for all auditory inputs to the MGB. However, recent anatomical evidence in the rat [ (Malmierca et al. 2002) J. Neurosci., 22, 10891-10897] has confirmed the presence of a direct pathway from the dorsal cochlear nucleus (DCN) to the medial MGB, bypassing the IC, as previously suggested in the chimpanzee [ (Strominger et al. 1977) J. Comp. Neurol., 172, 349-366]. We show that this direct pathway is also present in the guinea pig and apparently results in short latency responses in the thalamus. Injection of anterograde tracer into the DCN of five adult guinea pigs revealed terminal boutons and axonal swellings distributed throughout the medial MGB, but absent from all other MGB subdivisions. Electrophysiological recordings made from 39 adult guinea pigs (24 male & 15 female) showed neurons in the medial MGB responded with significantly shorter latencies to acoustic clicks (7.8 ms) than those from the ventral (11.0 ms), dorsal (14.4 ms), or shell (16.5 ms) MGB, consistent with the direct pathway from the DCN. The function of the direct pathway is not known but may be related to the fast responses and the role of the medial MGB in integrating combined somatosensory and auditory inputs. Short latency responses may be important in priming the auditory cortex to prepare it for rapid analysis and in recruiting the amygdala for rapid emotional responses such as fear.
机译：听觉丘脑（内侧膝状体，MGB）从下丘脑（IC）接收其主要的上升输入，认为下丘脑是所有向MGB的听觉输入的强制传递。然而，最近在大鼠中的解剖学证据[（Malmierca et al。2002）J. Neurosci。，22，10891-10897]证实存在从背侧耳蜗核（DCN）到内侧MGB的直接途径，绕过了IC，如先前在黑猩猩中所建议的（（Strominger等人，1977）J. Comp。 Neurol。，172，349-366]。我们显示该直接途径也存在于豚鼠中，并且显然导致丘脑中的短潜伏期反应。在五只成年豚鼠的DCN中注射顺行示踪剂后，发现在整个MGB内侧均分布有末梢突和轴突肿胀，但在所有其他MGB分区中却没有。用39只成年豚鼠（24头雄​​性和15头雌性）进行的电生理记录显示，内侧MGB的神经元对声click音（7.8 ms）的响应延迟明显短于从腹侧（11.0 ms），背侧（14.4 ms）或外壳（16.5 ms）MGB，与来自DCN的直接路径一致。直接途径的功能尚不清楚，但可能与快速反应以及内侧MGB在整合体感和听觉输入的整合中的作用有关。短暂的潜伏期反应对于启动听觉皮层以使其进行快速分析和招募杏仁核以进行快速的情绪反应（例如恐惧）可能很重要。

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