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首页> 外文期刊>The European Journal of Neuroscience >Early postnatal changes in respiratory activity in rat in vitro and modulatory effects of substance P.
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Early postnatal changes in respiratory activity in rat in vitro and modulatory effects of substance P.

机译：产后早期大鼠体外呼吸活动的变化以及P物质的调节作用。

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摘要

Developmental changes in the respiratory activity and its modulation by substance P (SP) were studied in the neonatal rat brainstem-spinal cord preparation from the day of birth to day 3 (P0-P3). The respiratory network activity in the ventrolateral medulla was represented by two types of bursts: basic regular bursts with typical decrementing shape and biphasic bursts appearing after augmented biphasic discharges in inspiratory neurons. With advancing postnatal age the respiratory output was considerably modified; the basic rhythm became faster by 20%, whereas the biphasic burst rate, which was originally 15 times slower, declined further by 180% and the C4 burst duration significantly decreased by 20% due to reduced decay time without preceding changes in the central inspiratory drive. SP had an age-dependent excitatory effect on respiratory activity. In the basic rhythm, SP could induce transient rhythm cessations on P0-P2 but not on P3. For the biphasic burst frequency, the sensitivity to SP significantly decreased from P0 to P3, whereas the range of SP-induced changes increased. In both types of bursts, SP prolonged C4 burst duration due to increasing decay time. This effect was three times greater on P3 and did not depend on the central inspiratory drive. Our results suggest that the potency of SP to regulate the respiratory activity elevates during the early postnatal period. The developmental changes in the respiratory activity appear to represent the transient stage in the maturation of rhythm and pattern generation mechanisms facilitating adaptive behavior of a quickly growing organism.
机译：从出生那天到第3天（P0-P3），研究了新生大鼠脑干-脊髓组织中呼吸活动的发育变化及其受P物质（SP）的调节。腹侧延髓的呼吸网络活动由两种类型的爆发代表：具有典型递减形状的基本规则爆发和在吸气神经元双相放电增加后出现的双相爆发。随着出生年龄的增长，呼吸输出量发生了很大变化。基本节律变快了20％，而原本要慢15倍的双相猝发率又下降了180％，由于衰减时间缩短了，而中央吸气驱动器却没有变化，C4猝发持续时间显着减少了20％。 。 SP对呼吸活动具有年龄依赖性的兴奋作用。在基本节律中，SP可以在P0-P2上引起短暂的节律停止，而在P3上则不会。对于双相突发频率，对SP的敏感性从P0显着降低到P3，而SP引起的变化范围增加。在两种类型的突发中，由于衰减时间增加，SP延长了C4突发持续时间。在P3上，这种效果要大三倍，并且与中央吸气驱动无关。我们的结果表明，在产后早期，SP调节呼吸活动的能力会提高。呼吸活动的发展变化似乎代表了节奏成熟和模式生成机制的过渡阶段，促进了快速生长的生物体的适应行为。

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