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首页> 外文期刊>The European Journal of Neuroscience >Diversity of laminar connections linking periarcuate and lateral intraparietal areas depends on cortical structure.
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Diversity of laminar connections linking periarcuate and lateral intraparietal areas depends on cortical structure.

机译：连接腹腔和侧顶壁区域的层流连接的多样性取决于皮质结构。

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Lateral prefrontal and intraparietal cortices have strong connectional and functional associations but it is unclear how their common visuomotor, perceptual and working memory functions arise. The hierarchical scheme of cortical processing assumes that prefrontal cortex issues 'feedback' projections to parietal cortex. However, the architectonic heterogeneity of these cortices raises the question of whether distinct areas have laminar-specific interconnections underlying their complex functional relationship. Using quantitative procedures, we showed that laminar-specific connections between distinct prefrontal (areas 46 and 8) and lateral intraparietal (LIPv, LIPd and 7a) areas in Macaca mulatta, studied with neural tracers, varied systematically according to rules determined by the laminar architecture of the linked areas. We found that axons from areas 46 and rostral 8 terminated heavily in layers I-III of all intraparietal areas, as did caudal area 8 to area LIPv, suggesting 'feedback' communication. However, contrary to previous assumptions, axons from caudal area 8 terminated mostly in layers IV-V of LIPd and 7a, suggesting 'feedforward' communication. These laminar patterns of connections were highly correlated with consistent differences in neuronal density between linked areas. When neuronal density in a prefrontal origin was lower than in the intraparietal destination, most terminations were found in layer I with a concomitant decrease in layer IV. The opposite occurred when the prefrontal origin had a higher neuronal density than the target. These findings indicate that the neuronal density of linked areas can reliably predict their laminar connections and may form the basis of understanding the functional complexity of prefrontal-intraparietal interactions in cognition.
机译：额叶前额皮质和顶叶内皮质之间具有很强的联系和功能联系，但尚不清楚它们共同的视觉运动，知觉和工作记忆功能如何产生。皮质处理的分层方案假定前额叶皮层向顶叶皮层发出“反馈”投影。但是，这些皮质的结构异质性提出了一个问题，即不同区域是否具有在其复杂功能关系下的特定于层流的互连。使用定量程序，我们显示了用神经示踪剂研究的猕猴中不同的额叶前额叶（区域46和8）与顶壁外侧区域（LIPv，LIPd和7a）之间的层流特异性连接，根据层流结构确定的规则系统地变化链接区域。我们发现，来自区域46和喙8的轴突在所有顶壁区域的I-III层中终止，尾区8到LIPv区域也是如此，提示“反馈”通信。然而，与先前的假设相反，来自尾区8的轴突主要终止于LIPd和7a的IV-V层，表明“前馈”通信。这些连接的层状模式与链接区域之间神经元密度的一致差异高度相关。当前额起源的神经元密度低于顶叶内目的地的神经元密度时，发现大部分终止于I层，伴随着IV层的减少。当前额叶起源的神经元密度高于目标密度时，情况恰恰相反。这些发现表明，连接区域的神经元密度可以可靠地预测它们的层状连接，并且可能构成了解认知中额叶-腹膜间相互作用功能复杂性的基础。

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