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首页> 外文期刊>The European Journal of Neuroscience >Identification of disabled-1 as a candidate gene for critical period neuroplasticity in cat and mouse visual cortex.
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Identification of disabled-1 as a candidate gene for critical period neuroplasticity in cat and mouse visual cortex.

机译：确定disabled-1作为猫和小鼠视觉皮层关键时期神经可塑性的候选基因。

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摘要

Rearing in darkness slows the time course of the critical period in visual cortex, such that at 5 weeks of age normal cats are more plastic than dark-reared cats, whereas at 20 weeks dark-reared cats are more plastic [G. D. Mower (1991)Dev. Brain Res., 58, 151-158]. Thus, a stringent criterion is that genes that are important for plasticity in visual cortex will show differences in expression between normal and dark-reared visual cortex that are of opposite direction in young vs. older animals. The present study reports the identification by differential display PCR of Dab-1, the mammalian homolog of the drosophila disabled-1 gene, as a candidate gene for critical period neuronal plasticity, expression of which is regulated according to this criterion in cat visual cortex. Evidence for this bidirectional direction regulation is extended to Dab-1 protein in cat and mouse visual cortex and shown to be specific to visual cortex, not occurring in frontal cortex. The Reelin/Dab-1 pathway has well-documentedfunctions in cell migration during prenatal life and increasing evidence indicates that in postnatal brain the pathway plays a role in synaptic plasticity. The present results extend this evidence by directly implicating Dab-1 in postnatal critical period plasticity of visual cortex.
机译：在黑暗中饲养会减慢视觉皮层关键时期的时间，因此，在5周龄时，正常猫比在黑暗中饲养的猫更具塑性，而在20周时，黑暗饲养的猫则具有更高的塑性[G. D.割草机（1991） [Brain Res。，58，151-158]。因此，一个严格的标准是，对于视觉皮层可塑性重要的基因将显示正常和深色饲养的视觉皮层之间的表达差异，而在年轻与年长动物中，该方向相反。本研究报告通过差异显示PCR鉴定果蝇disabled-1基因的哺乳动物同源物Dab-1，作为关键时期神经元可塑性的候选基因，其表达在猫视皮层中根据该标准进行调节。这种双向方向调节的证据扩展到了猫和小鼠视觉皮层中的Dab-1蛋白，并显示出对视觉皮层具有特异性，而不在额叶皮层中发生。 Reelin / Dab-1途径在产前生命中具有良好的细胞迁移功能，并且越来越多的证据表明，在产后大脑中，该途径在突触可塑性中起作用。本研究结果通过直接将Dab-1牵涉到视皮层的产后关键期可塑性中来扩展了这一证据。

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