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首页> 外文期刊>The European Journal of Neuroscience >Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon.
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Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon.

机译：乙醇戒断可引起PKCepsilon介导的痛觉过敏。

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摘要

Symptoms of ethanol withdrawal include heightened responses to sensory stimuli, as well as tremors and convulsions. We tested the hypothesis that repeated episodes of ethanol intake and withdrawal exacerbate the symptoms of alcohol-induced peripheral neuropathy. In contrast to the hyperalgesia produced when an alcohol (6.5%)-containing diet was fed continuously to male rats which took 4 weeks to develop (Dina et al., 2000), feeding alcohol (6.5%) in repeated cycles of 4 days of alcohol followed by 3 days without alcohol resulted in a withdrawal-induced hyperalgesia that began at the end of one weekly cycle and reached a maximum during the fourth cycle. For ethanol withdrawal to produce hyperalgesia, ethanol consumption needed to be terminated for a period of 2 days. Paradoxically, as the amount of alcohol consumed decreased, the hyperalgesia induced by withdrawal developed more rapidly, being maximal between 1.4 and 1.6% ethanol. These results suggest that continued exposure to ethanol also has a neuroprotective effect. Withdrawal-induced hyperalgesia, similar to the hyperalgesia induced by continuous, chronic alcohol intake, was inhibited reversibly by intrathecal administration of an antisense oligodeoxynucleotide to protein kinase C (PKC)epsilon.
机译：乙醇戒断的症状包括对感觉刺激的反应增强，以及震颤和抽搐。我们检验了乙醇摄入和戒断的反复发作加剧酒精引起的周围神经病症状的假设。与将含酒精（6.5％）的饮食连续喂给需要4周发育的雄性大鼠产生的痛觉过敏相反（Dina et al。，2000），以4天的重复周期喂食酒精（6.5％）。酒后三天不喝酒会导致戒断所致的痛觉过敏，这种痛觉过敏从每周一次的周期结束时开始，在第四个周期达到最大值。为了戒断乙醇以产生痛觉过敏，需要停止使用乙醇2天。矛盾的是，随着饮酒量的减少，戒断引起的痛觉过敏发展得更快，乙醇含量最高在1.4％至1.6％之间。这些结果表明，持续接触乙醇也具有神经保护作用。通过鞘内向蛋白激酶C（PKC）ε鞘内施用反义寡脱氧核苷酸，可逆地抑制戒断诱发的痛觉过敏，类似于持续不断饮酒引起的痛觉过敏。

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