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首页> 外文期刊>The European Journal of Neuroscience >Dopamine neuronal responses in monkeys performing visually cued reward schedules.
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Dopamine neuronal responses in monkeys performing visually cued reward schedules.

机译：执行视觉提示奖励计划的猴子中的多巴胺神经元反应。

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Dopamine neurons are important for reward-related behaviours. They have been recorded during classical conditioning and operant tasks with stochastic reward delivery. However, daily behaviour, although frequently complex in the number of steps, is often very predictable. We studied the responses of 75 dopamine neurons during schedules of trials in which the events and related reward contingencies could be well-predicted, within and across trials. In this visually cued reward schedule task, a visual cue tells the monkeys exactly how many trials, 1, 2, 3, or 4, must be performed to obtain a reward. The number of errors became larger as the number of trials remaining before the reward increased. Dopamine neurons frequently responded to the cues at the beginning and end of the schedules. Approximately 75% of the first-cue responsive neurons did not distinguish among the schedules that were beginning even though the cues were different. Approximately half of the last-cue responsive neurons depended on whichschedule was ending, even though the cue signalling the last trial was the same in all schedules. Thus, the responses were related to what the monkey knew about the relation between the cues and the schedules, not the identity of the cues. These neurons also frequently responded to the go signal and/or to the OK signal indicating the end of a correctly performed trial whether a reward was forthcoming or not, and to the reward itself. Thus, dopamine neurons seem to respond to behaviourally important, i.e. salient, events even when the events have been well-predicted.
机译：多巴胺神经元对于与奖赏相关的行为很重要。它们已在经典条件和操作任务中以随机奖励交付方式记录下来。但是，日常行为尽管步数通常很复杂，但通常是非常可预测的。我们在试验计划中研究了75种多巴胺神经元的反应，其中事件和相关的奖励意外事件可以在试验中和试验之间得到很好的预测。在此视觉提示的奖励计划任务中，视觉提示准确地告诉猴子必须进行多少次试验，1、2、3或4才能获得奖励。奖励增加之前，剩余的尝试次数越多，错误的数量就会越大。多巴胺神经元经常在时间表的开始和结束时对提示做出反应。即使提示有所不同，大约75％的第一提示反应神经元也无法区分开始的时间表。尽管提示最后一次试验的提示在所有时间表中都是相同的，但大约有一半的最后提示响应神经元取决于时间表的结束时间。因此，响应与猴子对线索与时间表之间关系的了解有关，而不与线索的身份有关。这些神经元还频繁地对执行信号和/或确定信号做出响应，以指示正确执行的试验是否会结束，以及是否会获得奖励。因此，即使事件已经被很好地预测，多巴胺神经元似乎也对行为上重要的事件即显着事件做出反应。

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