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首页> 外文期刊>The European Journal of Neuroscience >Rapid-rate transcranial magnetic stimulation of animal auditory cortex impairs short-term but not long-term memory formation.
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Rapid-rate transcranial magnetic stimulation of animal auditory cortex impairs short-term but not long-term memory formation.

机译：对动物的听觉皮层进行快速颅磁刺激会损害短期记忆，但不会损害长期记忆。

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Bilateral rapid-rate transcranial magnetic stimulation (rTMS) of gerbil auditory cortex with a miniature coil device was used to study short-term and long-term effects on discrimination learning of frequency-modulated tones. We found previously that directional discrimination of frequency modulation (rising vs. falling) relies on auditory cortex processing and that formation of its memory depends on local protein synthesis. Here we show that, during training over 5 days, certain rTMS regimes contingent on training had differential effects on the time course of learning. When rTMS was applied several times per day, i.e. four blocks of 5 min rTMS each followed 5 min later by a 3-min training block and 15-min intervals between these blocks (experiment A), animals reached a high discrimination performance more slowly over 5 days than did controls. When rTMS preceded only the first two of four training blocks (experiment B), or when prolonged rTMS (20 min) preceded only the first block, or when blocks of experiment A had longer intervals (experiments C and D), no significant day-to-day effects were found. However, in experiment A, and to some extent in experiment B, rTMS reduced the within-session discrimination performance. Nevertheless the animals learned, as demonstrated by a higher performance the next day. Thus, our results indicate that rTMS treatments accumulate over a day but not strongly over successive days. We suggest that rTMS of sensory cortex, as used in our study, affects short-term memory but not long-term memory formation.
机译：使用小型线圈装置对沙鼠听觉皮层进行双边快速经颅磁刺激（rTMS），以研究短期和长期对调频音的判别学习的影响。我们以前发现，频率调制的定向辨别（上升与下降）取决于听觉皮层的处理，其记忆的形成取决于局部蛋白质的合成。在这里，我们表明，在为期5天的训练中，某些取决于训练的rTMS方案对学习的时程有不同的影响。每天几次使用rTMS时，即四个块，每块5分钟，rTMS分别在5分钟后进行3分钟的训练，这些块之间的间隔为15分钟（实验A），动物在达到较高的辨别能力时会更慢比对照组多5天。当rTMS仅在四个训练块中的前两个训练之前（实验B），或者延长的rTMS（20分钟）仅在第一个训练块之前，或者当实验A的块具有较长的间隔（实验C和D）时，发现了今天的影响。但是，在实验A中，并且在某种程度上在实验B中，rTMS降低了会话内的辨别性能。尽管如此，这些动物还是学会了，第二天表现更高。因此，我们的结果表明，rTMS治疗在一天中积累起来，但在连续几天中却没有增长。我们建议在我们的研究中使用的感觉皮层的rTMS影响短期记忆，但不会影响长期记忆的形成。

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