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首页> 外文期刊>The European Journal of Neuroscience >Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease.
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Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease.

机译：丘脑下刺激刺激帕金森病患者黑质网状组织的生化和电生理变化。

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摘要

To understand the events underlying the clinical efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN), electrophysiological recordings and microdialysis evaluations were carried out in the substantia nigra pars reticulata (SNr), one of the two basal ganglia (BG) nuclei targeted by STN output, in patients with Parkinson's disease (PD). Clinically effective STN-DBS caused a significant increase of the SNr firing rate. The poststimulus histogram (PSTH) showed an excitation peak at 1.92-3.85 ms after the STN stimulus. The spontaneous discharge of SNr neurons was driven at the frequency of the stimulation (130 Hz), as shown in the autocorrelograms (AutoCrl). The fast Fourier transform (FFT) analysis showed a peak at 130 Hz, and a less pronounced second one at 260 Hz. Accordingly, in the distribution of the interspike intervals (ISIs), the mode was earlier, and skewness more asymmetric. Biochemically, the increased excitatory driving from the STN was reflected by a clear-cut increase in cyclic guanosine 3',5'-monophosphate (cGMP) levels in the SNr. These results indicate that the beneficial effect of DBS in PD patients is paralleled with a stimulus-synchronized activation of the STN target, SNr. Our findings suggest that, during STN-DBS, a critical change towards a high-frequency oscillatory discharge occurs.
机译：为了了解丘脑底核（STN）的深层脑刺激（DBS）的临床疗效的潜在事件，在两个基底神经节（BG）之一的黑质网状组织（SNr）中进行了电生理记录和微透析评估。帕金森氏病（PD）患者的STN输出所靶向的细胞核。临床上有效的STN-DBS导致SNr放电率显着提高。刺激后直方图（PSTH）在STN刺激后的1.92-3.85 ms处显示出一个激发峰。 SNr神经元的自发放电以刺激频率（130 Hz）驱动，如自相关图（AutoCrl）所示。快速傅立叶变换（FFT）分析显示在130 Hz处有一个峰值，而在260 Hz处没有那么明显的第二个。因此，在尖峰间隔（ISI）的分布中，模式更早，并且偏度更加不对称。生化方面，来自STN的兴奋性驱动力增加反映为SNr中环状鸟苷3'，5'-单磷酸（cGMP）含量明显增加。这些结果表明，DBS在PD患者中的有益作用与STN目标SNr的刺激同步激活相平行。我们的发现表明，在STN-DBS期间，发生了向高频振荡放电的关键变化。

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