...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission.
【24h】

Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission.

机译：运动活动与海马苔藓纤维突触传递的改变有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The hippocampus has long been implicated in memory formation. Although accumulating evidence suggests involvement of the hippocampus in other brain functions including locomotor regulation and emotional processes, cellular and synaptic bases underlying these functions remain largely unknown. We here report that environmental manipulations in mice unveiled the association of locomotor activity with the hippocampal mossy fibre (MF) synaptic transmission. Electrophysiological recordings of synaptic responses were made using hippocampal slices prepared from mice whose behaviour had been analysed. Environmental enrichment induced parallel decreases in open-field locomotor activity and MF synaptic facilitation. Facilitation induced by paired-pulse stimulation at relatively long intervals (>or=200 ms) was selectively reduced while the basal synaptic efficacy and high-frequency transmission were unaffected. Social isolation caused a change in behaviour in an elevated plus-maze, but neither the open-field activity nor the MF synaptic transmission was significantly altered. Effects of dopamine, a neurotransmitter essential for locomotor regulation, on the MF synapse were also examined using these mice. Environmental manipulations did not cause significant changes in potentiation of the MF synaptic transmission induced by dopamine. However, analysis of behavioural and electrophysiological results in individual subjects revealed that locomotor activity negatively correlates with magnitude of the dopamine-induced potentiation. These results suggest that the MF synapse plays important roles in the regulation of locomotor activity. We propose that the MF synapse can serve as the synaptic model for certain forms of locomotor regulation, with potential importance for investigation of the pathophysiology of psychiatric diseases using animal models.
机译：长期以来，海马与记忆形成有关。尽管越来越多的证据表明海马体参与了其他脑功能，包括运动调节和情绪过程，但这些功能所基于的细胞和突触基础仍然未知。我们在这里报告，小鼠的环境操纵揭示了自发活动与海马苔藓纤维（MF）突触传递的关联。使用从已对其行为进行了分析的小鼠制备的海马切片进行突触反应的电生理记录。环境富集导致开阔地运动活动和MF突触促进平行减少。在相对较长的时间间隔（> == 200 ms）下，成对脉冲刺激诱导的促进作用选择性降低，而基础突触功效和高频传导则不受影响。社会隔离导致高迷宫行为的改变，但旷野活动和MF突触传递均未得到明显改变。使用这些小鼠还检查了多巴胺（对运动调节至关重要的神经递质）对MF突触的影响。环境操作并没有引起多巴胺诱导的MF突触传递增强的显着变化。但是，对个别受试者的行为和电生理结果的分析显示，运动活动与多巴胺诱导的增强作用呈负相关。这些结果表明，MF突触在运动活性的调节中起重要作用。我们建议，MF突触可以作为某些形式的运动调节的突触模型，对于使用动物模型研究精神疾病的病理生理学具有潜在的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号