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首页> 外文期刊>The European Journal of Neuroscience >Enhancement of conditioned fear extinction by infusion of the GABA agonist muscimol into the rat prefrontal cortex and amygdala.
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Enhancement of conditioned fear extinction by infusion of the GABA agonist muscimol into the rat prefrontal cortex and amygdala.

机译：通过将GABA激动剂麝香酚注入大鼠前额叶皮层和杏仁核，增强条件性恐惧的消除。

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摘要

In auditory fear conditioning, repeated presentation of the tone in the absence of the shock leads to extinction of the acquired fear response. Both the infra limbic prefrontal cortex (IL) and the basolateral amygdala (BLA) are involved in extinction. In this study, we examine the involvement of these two regions in extinction by manipulating the gamma-aminobutyric acid (GABA)ergic system, in the Sprague-Dawley rat. We microinfused a low dose of the GABA(A) agonist muscimol into the IL or BLA. Muscimol infused to IL before extinction training, but not after either a short (five-trials) or long (15-trials) extinction training, resulted in long-term facilitation of extinction. Infusion of muscimol to the BLA following a short (five-trial) extinction session facilitated extinction at least 48-h post-drug infusion. The differences in the temporal parameters of the effects of muscimol in the IL or BLA, suggest differential involvement of these structures in long-term extinction of fear memory. We propose a facilitating role for GABA(A) neurotransmission in the IL in triggering the onset of fear extinction and its maintenance, whereas in the BLA, GABA(A) neurotransmission facilitates extinction consolidation. The involvement of GABA(A) receptors in fear extinction in the prefrontal cortex and amygdala is of particular interest, because of the role of these areas in emotional processes, and the role of the GABA(A) receptors in anxiety states.
机译：在听觉恐惧调节中，在没有电击的情况下反复出现提示音会导致获得的恐惧反应消失。下缘前额叶皮层（IL）和基底外侧杏仁核（BLA）均参与灭绝。在这项研究中，我们通过操纵Sprague-Dawley大鼠中的γ-氨基丁酸（GABA）能量系统来检查这两个区域在灭绝中的参与。我们将低剂量的GABA（A）激动剂麝香酚微注入IL或BLA中。在灭绝训练之前向IL注入Muscimol，但短期（5次试验）或长期（15次试验）灭绝训练后未注射麝香酚，可长期促进灭绝。在短暂（五次试验）灭绝后，向BLA注入麝香酚可促进药物输注后至少48小时的灭绝。麝香酚对IL或BLA的作用在时间参数上的差异表明，这些结构在恐惧记忆的长期消退中具有不同的参与。我们提出促进IL的GABA（A）神经传递在触发恐惧消退及其维持的发作中的促进作用，而在BLA中，GABA（A）神经传递则有助于消灭巩固。 GABA（A）受体参与前额叶皮层和杏仁核的恐惧消灭特别令人感兴趣，因为这些区域在情绪过程中的作用以及GABA（A）受体在焦虑状态中的作用。

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