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首页> 外文期刊>The European Journal of Neuroscience >Net influx of plasma 6-(18F)fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli.
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Net influx of plasma 6-(18F)fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli.

机译：血浆6-（18F）氟-L-DOPA（FDOPA）向腹侧纹状体的净流入与情感刺激的前额叶加工有关。

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摘要

Dopaminergic neurotransmission in the ventral and dorsal striatum interact with central processing of rewarding and reward-indicating stimuli, and may affect frontocortical-striatal-thalamic circuits regulating goal-directed behaviour. Thirteen healthy male volunteers were investigated with multimodal imaging, using the radioligand 6-[(18)F]fluoro-l-DOPA (FDOPA) for positron emission tomography (PET) measurements of dopamine synthesis capacity, and also functional magnetic resonance imaging (fMRI) in a cognitive activation paradigm. We calculated the correlation between FDOPA net blood-brain influx (; ml/g/min) in the ventral and associative dorsal striatum and BOLD signal changes elicited by standardized affectively positive, negative and neutral visual stimuli. The magnitude of in the ventral striatum was positively correlated with BOLD signal increases in the left anterior cingulate cortex and right insular operculum elicited by positive vs. neutral stimuli, but not negative vs. neutral stimuli. In the dorsal striatum, the magnitude of was positively correlated with processing of positive and negative stimuli in the left dorsolateral prefrontal cortex. These findings suggest that dopamine synthesis capacity in the ventral striatum correlates with the attentional processing of rewarding positive stimuli in the anterior cingulate cortex of healthy subjects. Dopaminergic neurotransmission in the associative dorsal striatum has been associated previously with habit learning. The observed correlation between dopamine synthesis capacity in the dorsal striatum and BOLD signal changes in the dorsolateral prefrontal cortex suggests dopaminergic modulation of processing of emotional stimuli in brain areas associated with motor planning and executive behaviour control.
机译：腹侧和背侧纹状体中的多巴胺能神经传递与奖励和奖励指示刺激的中央处理相互作用，并可能影响调节目标定向行为的额皮质-纹状体-丘脑回路。使用放射配体6-[[（18）F]氟-1-DOPA（FDOPA）对多巴胺合成能力进行正电子发射断层扫描（PET）测量，以及功能磁共振成像（fMRI），对13名健康男性志愿者进行了多模式成像研究。 ）在认知激活范例中。我们计算了腹侧和相关背侧纹状体的FDOPA净血脑流入（; ml / g / min）与标准化情感性正，负和中性视觉刺激引起的BOLD信号变化之间的相关性。腹侧纹状体的大小与正刺激与中性刺激引起的左前扣带回皮层和右岛小肠oper骨中的BOLD信号增加呈正相关，但与负刺激与中性刺激无关。在背侧纹状体中，其大小与左侧背外侧前额叶皮层中正刺激和负刺激的处理呈正相关。这些发现表明，腹侧纹状体中的多巴胺合成能力与健康受试者的前扣带回皮层中奖励积极刺激的注意过程相关。先前已经在习惯性学习中关联了背侧纹状体中的多巴胺能神经传递。观察到的纹状体背侧多巴胺合成能力与背外侧前额叶皮层中BOLD信号变化之间的相关性表明，多巴胺能调节与运动计划和执行行为控制相关的大脑区域情绪刺激的处理。

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