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首页> 外文期刊>The European Journal of Neuroscience >Hippocampal CA3 pyramidal cells selectively innervate aspiny interneurons.
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Hippocampal CA3 pyramidal cells selectively innervate aspiny interneurons.

机译：海马CA3锥体细胞选择性地支配棘突间神经元。

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摘要

The specific connectivity among principal cells and interneurons determines the flow of activity in neuronal networks. To elucidate the connections between hippocampal principal cells and various classes of interneurons, CA3 pyramidal cells were intracellularly labelled with biocytin in anaesthetized rats and the three-dimensional distribution of their axon collaterals was reconstructed. The sections were double-stained for substance P receptor (SPR)- or metabotropic glutamate receptor 1alpha (mGluR-1alpha)-immunoreactivity to investigate interneuron targets of the CA3 pyramidal cells. SPR-containing interneurons represent a large portion of the GABAergic population, including spiny and aspiny classes. Axon terminals of CA3 pyramidal cells contacted SPR-positive interneuron dendrites in the hilus and in all hippocampal strata in both CA3 and CA1 regions (7.16% of all boutons). The majority of axons formed single contacts (87.5%), but multiple contacts (up to six) on single target neurons were also found. CA3 pyramidal cell axon collaterals innervated several types of morphologically different aspiny SPR-positive interneurons. In contrast, spiny SPR-interneurons or mGluR-1alpha-positive interneurons in the hilus, CA3 and CA1 regions were rarely contacted by the filled pyramidal cells. These findings indicate a strong target selection of CA3 pyramidal cells favouring the activation of aspiny classes of interneurons.
机译：主细胞和中间神经元之间的特定连通性决定了神经元网络中的活动流。为了阐明海马主细胞和各种类型的中间神经元之间的联系，在麻醉的大鼠中用生物素标记CA3锥体细胞，并重建其轴突侧支的三维分布。这些切片对物质P受体（SPR）-或代谢型谷氨酸受体1alpha（mGluR-1alpha）-免疫反应性进行了双重染色，以研究CA3锥体细胞的中间神经元靶标。含SPR的中间神经元代表GABA能人群的大部分，包括棘突和棘突类。 CA3锥体细胞的轴突末端与CA3和CA1地区（占全部钮扣的7.16％）的希拉斯和所有海马层的SPR阳性中神经元树突接触。多数轴突形成单一接触（87.5％），但在单个靶神经元上也发现多个接触（最多六个）。 CA3锥体细胞轴突侧支神经支配几种类型的形态学不同的棘状SPR阳性中间神经元。相比之下，在us，CA3和CA1区的多刺SPR-interneurons或mGluR-1alpha阳性interneurons很少与填充的锥体细胞接触。这些发现表明，对CA3锥体细胞的强烈靶选择有利于激活神经元的棘突类。

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