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首页> 外文期刊>The European Journal of Neuroscience >Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats.
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Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats.

机译：海马背侧和腹侧损伤对大鼠防御行为的影响。

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摘要

This study investigated the role of the hippocampus in both unconditioned and conditioned defensive behaviors by examining the effects of pretraining ibotenic acid lesions to the dorsal and ventral hippocampus in male Long-Evans hooded rats exposed to three types of threat stimuli: cat-odor, a live cat and footshock. Defensive behaviors were assessed during exposure to cat-odor and a live cat, and immediately following the presentation of footshock. Conditioned defensive behaviors were also assessed in each context 24 h after initial threat exposure. During both unconditioned and conditioned trials, dorsal hippocampal lesions failed to significantly alter any behavioral measure in each test of defense. In contrast, ventral hippocampal lesions significantly reduced unconditioned defensive behaviors during exposure to cat-odor without producing any observable effects during cat exposure. Furthermore, ventral lesions significantly attenuated conditioned defensive behaviors following the administration of footshock and during re-exposure to each context. These results suggest a specific role for the ventral, not dorsal, hippocampus in modulating anxiety-like behaviors in certain animal models of defense.
机译：这项研究通过检查暴露于三种类型威胁刺激的雄性Long-Evans蒙面雄性大鼠的预先训练的ibotenic acid损伤对背侧和腹侧海马的影响，研究了海马在无条件和有条件的防御行为中的作用。活猫和脚踩电击。在暴露于猫味和一只活猫期间，以及出现手震后立即评估防御行为。在初始威胁暴露后24小时内，还应在每种情况下评估条件防御行为。在无条件和有条件的试验中，海马背侧病变在每次防御测试中均无法显着改变任何行为指标。相比之下，腹侧海马损伤显着降低了猫气味暴露期间的无条件防御行为，而在猫暴露期间未产生任何可观察到的影响。此外，腹壁损伤在给予足部电击之后以及在再次暴露于每种情况下显着减弱了条件防御行为。这些结果表明，在某些防御动物模型中，腹侧而不是背侧海马在调节焦虑样行为中具有特定作用。

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