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首页> 外文期刊>The European Journal of Neuroscience >Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina.
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Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina.

机译：光周期史对大鼠视网膜时钟基因和昼夜节律起搏器的影响。

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摘要

The influence of seasonal lighting conditions on expression of clock genes and the circadian pacemaker was investigated in the rat retina. For this purpose, the 24-h profiles of nine clock genes (bmal1, clock, per1, per2, per3, dec1, dec2, cry1 and cry 2) and the arylalkylamine N-acetyltransferase gene as an indicator of the circadian pacemaker output were compared between light-dark periods of 8 : 16 and 16 : 8 h. The photoperiod influenced the daily patterns of the amount of transcript for per1, per3, dec2 and arylalkylamine N-acetyltransferase. This indicates that photoperiodic information modulates clock gene expression in addition to the circadian pacemaker of the retina. Under constant darkness, photoperiod-dependent changes in the daily profile of the level of transcript persisted for the arylalkylamine N-acetyltransferase gene but not for any of the clock genes. Hence, quantitative expression of each clock gene is influenced by the photoperiod only under the acute light-dark cycle, whereas the pacemaker is capable of storing photoperiodic information from past cycles.
机译：在大鼠视网膜中研究了季节性光照条件对时钟基因和昼夜节律起搏器表达的影响。为此，比较了九种时钟基因（bmal1，clock，per1，per2，per3，dec1，dec2，cry1和cry2）和作为昼夜节律起搏器输出指标的芳基烷基胺N-乙酰基转移酶基因的24小时配置文件在8:16和16：8 h的黑暗时段之间。光周期影响per1，per3，dec2和芳基烷基胺N-乙酰基转移酶的转录量的每日模式。这表明光周期信息除了调节视网膜的生物钟起搏器外，还调节时钟基因的表达。在恒定的黑暗中，对于芳基烷基胺N-乙酰基转移酶基因而言，转录水平每日概况的光周期依赖性变化持续存在，而对于任何时钟基因均不存在。因此，每个时钟基因的定量表达仅在急性明暗周期下受光周期的影响，而起搏器能够存储过去周期的光周期信息。

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