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首页> 外文期刊>The European Journal of Neuroscience >Neuropeptide Y in the olfactory microvillar cells.
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Neuropeptide Y in the olfactory microvillar cells.

机译：嗅微绒毛细胞中的神经肽Y。

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摘要

This paper examines a possible role of microvillar cells in coordinating cell death and regeneration of olfactory epithelial neurons. The olfactory neuroepithelium of mammals is a highly dynamic organ. Olfactory neurons periodically degenerate by apoptosis and as a consequence of chemical or physical damage. To compensate for this loss of cells, the olfactory epithelium maintains a lifelong ability to regenerate from a pool of resident multipotent stem cells. To assure functional continuity and histological integrity of the olfactory epithelium over a period of many decades, apoptosis and regeneration require to be precisely coordinated. Among the factors that have been implicated in mediating this regulation is the neuropeptide Y (NPY). Knockout mice that lack functional expression of this neurogenic peptide show defects in embryonic development of the olfactory epithelium and in its ability to regenerate in the adult. Here we show that, in postnatal olfactory epithelia, NPY is exclusively expressed by a specific population of microvillar cells. We previously characterized these cells as a novel type of putative chemosensory cells, which are provided with a phosphatidyl-inositol-mediated signal transduction cascade. Our findings allow for the first time to suggest that microvillar cells are involved in connecting apoptosis to neuronal regeneration by stimulus-induced release of NPY.
机译：本文研究了微绒毛细胞在协调嗅觉上皮神经元细胞死亡和再生中的可能作用。哺乳动物的嗅觉神经上皮是高度动态的器官。嗅觉神经元由于细胞凋亡以及化学或物理损伤的结果而周期性地退化。为了补偿细胞的这种损失，嗅觉上皮维持了从驻留的多能干细胞库再生的终生能力。为了确保数十年来嗅觉上皮的功能连续性和组织学完整性，需要精确协调细胞凋亡和再生。在涉及调节这种调节的因素中有神经肽Y（NPY）。缺乏这种神经源性肽的功能性表达的基因敲除小鼠在嗅觉上皮的胚胎发育及其在成年人中再生的能力方面表现出缺陷。在这里，我们显示，在产后嗅觉上皮细胞中，NPY仅由特定的微绒毛细胞群体表达。我们以前将这些细胞表征为一种新型的假定的化学感觉细胞，它具有磷脂酰肌醇介导的信号转导级联反应。我们的发现首次表明微绒毛细胞通过刺激诱导的NPY释放参与细胞凋亡与神经元再生的连接。

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