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首页> 外文期刊>The European Journal of Neuroscience >Novel temporal configurations of stimuli produce discrete changes in immediate-early gene expression in the rat hippocampus.
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Novel temporal configurations of stimuli produce discrete changes in immediate-early gene expression in the rat hippocampus.

机译：新型的时间配置刺激在大鼠海马中的早期基因表达中产生离散变化。

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Changes in limbic brain activity in response to novel configurations of visual stimuli were assessed by quantifying two immediate-early genes, c-fos and zif268. Rats were first trained to use distal, visual cues to support radial-arm maze performance. Two separate sets of visual cues were used, one in the morning (Set A) and the other in the afternoon (Set B). On the final day the experimental group was tested with a novel configuration created by combining four of the eight visual cues from Set A with four of the eight visual cues from Set B. Although each individual cue was in a familiar location, the combination of cues was novel. Comparisons with a control group revealed discrete decreases in Fos centred in the hippocampus and retrosplenial cortex. The hippocampal c-fos findings produced a dissociation with the perirhinal cortex, where no change was observed. Other regions seemingly unaffected by the novel stimulus configuration included the postrhinal, entorhinal and parietal cortices. Zif268 levels in the experimental group increased in the anterior ventral thalamic nucleus. Although previous studies have shown how the rat hippocampus is involved in responding to the spatial rearrangement of visual stimuli, the present study examined temporal rearrangement. The selective immediate-early gene changes in the hippocampus and two closely related sites (retrosplenial cortex and anterior ventral thalamic nucleus) when processing the new stimulus configuration support the notion that the hippocampus is important for learning the 'relational' or 'structural' features of arrays of elements, be they spatial or temporal.
机译：通过量化两个即刻早期基因c-fos和zif268，评估了对视觉刺激的新颖构型的边缘大脑活动的变化。首先训练大鼠使用远侧视觉提示来支持radial臂迷宫表演。使用了两组独立的视觉提示，一组在早上（A组），另一组在下午（B组）。在最后一天，实验组通过组合来自A组的八个视觉提示中的四个与来自B组的八个视觉提示中的四个创建的新颖配置进行了测试。尽管每个单独的提示都位于熟悉的位置，但是这些提示的组合是新颖的。与对照组的比较显示，以海马和脾后皮质为中心的Fos离散降低。海马c-fos的发现与周围皮层分离，未观察到变化。似乎不受新的刺激配置影响的其他区域包括后皮质，内嗅皮质和顶叶皮质。实验组的Zif268水平在前腹丘脑核中增加。尽管先前的研究表明大鼠海马体如何参与视觉刺激的空间重排，但本研究还是研究了时间重排。当处理新的刺激配置时，海马和两个紧密相关的部位（后脾皮层和前腹丘脑核）的选择性即刻早期基因改变支持这种观点，即海马对于学习海马的“关系”或“结构”特征很重要。元素的数组，无论是空间的还是时间的。

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