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首页> 外文期刊>The European Journal of Neuroscience >Maturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in rats.
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Maturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in rats.

机译：耳石相关脑干神经元的成熟在大鼠垂直线性加速度的检测中。

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摘要

To investigate the critical maturation time of otolith-related neurons in processing vertical orientations, rats (postnatal day 4 to adults) were studied for functional activation of c-fos expression in brainstem neurons by immuno-/hybridization histochemistry. Conscious rats were subjected to sinusoidal linear acceleration along the vertical plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming an otolithic origin of c-fos expression. Functionally activated Fos expression in neurons of the medial and spinal vestibular nuclei and group x were identifiable by P7 and those in group y by P9. A small number of Fos-labeled neurons characterized by small soma size were found in the ventral part of lateral vestibular nucleus by P9. Other vestibular-related areas such as prepostitus hypoglossal nucleus, gigantocellular reticular nucleus and locus coeruleus of normal experimental rats showed functionally activated c-fos expression at P7. Neurons in dorsal medial cell column and beta subnucleus of the inferior olive only showed functionally activated c-fos expression by the second postnatal week. These findings revealed a unique critical maturation time for each of the vestibular-related brainstem areas in the recognition of gravity-related vertical head orientations. By mapping the three-dimensional distribution of Fos-immunoreactive neurons, we found an even distribution of otolith-related neurons within the spinal vestibular nucleus in groups x and y but a clustered distribution in the middle-lateral-ventral part of the medial vestibular nucleus. Taken together, our findings reveal the developmental profile of neuronal subpopulations within the vertical otolith system, thereby providing an anatomical basis for postnatal coding of gravity-related vertical head movements.
机译：为了研究耳石相关神经元在处理垂直方向上的关键成熟时间，研究了大鼠（出生后第4天到成年）通过免疫/杂交组织化学对脑干神经元中c-fos表达的功能激活。有意识的大鼠沿垂直平面受到正弦线性加速度。迷路切除术和/或固定对照仅在前庭核中散在散布的Fos标记神经元，证实了c-fos表达的耳石起源。通过P7可以识别内侧和脊椎前庭核神经元和x组中功能激活的Fos表达，而通过y9可以识别y组中的功能激活的Fos表达。通过P9在前庭外侧核的腹侧部分发现了少量以Fos标记的神经元，其特征是体小。正常实验大鼠的其他前庭相关区域，例如，prepostitus舌下丘核，巨细胞网状核和蓝斑轨迹，在P7处均显示了功能激活的c-fos表达。产后第二周，背橄榄内侧细胞列和下橄榄β亚核中的神经元仅显示功能性激活的c-fos表达。这些发现揭示了在识别与重力有关的垂直头方向时，每个与前庭有关的脑干区域都有一个独特的临界成熟时间。通过绘制Fos免疫反应性神经元的三维分布图，我们发现在x和y组中脊柱前庭核内耳石相关神经元的均匀分布，但在前庭内侧核的中外侧腹部分呈簇状分布。综上所述，我们的发现揭示了垂直耳石系统内神经元亚群的发育情况，从而为产后重力相关的垂直头运动编码提供了解剖学基础。

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