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首页> 外文期刊>The European Journal of Neuroscience >Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system.
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Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system.

机译：饮食限制改变了脑源性神经营养因子杂合小鼠的行为：血清素能系统的作用。

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Accumulating evidence has suggested that brain-derived neurotrophic factor (BDNF) plays a role in eating behaviours, and that BDNF-heterozygous (+/-) mice exhibit abnormal behaviours (e.g. obesity, anxiety and aggression). The present study was undertaken to determine whether or not dietary restriction (DR) alters the behaviours in BDNF(+/-) mice, as DR has been shown to exert a number of beneficial effects on the brain. Eight-week-old male wild-type (+/+) and BDNF(+/-) mice were divided into two groups, ad libitum (AL) diet group and DR group, for 16 weeks. After carrying out a behavioural evaluation, we determined the BDNF mRNA levels, as well as mRNA levels for subtypes (5-HT(1A), 5-HT(1B), 5-HT(2A) and 5-HT(2C)) of the 5-HT receptor and 5-HT transporter (5-HTT), protein levels of BDNF and concentrations of 5-HT and 5-HIAA in the hypothalamus, hippocampus and frontal cortex. DR significantly ameliorated behaviours including obesity, anxiety and aggression in BDNF(+/-) mice. The concentrations of 5-HT and 5-HIAA in the frontal cortex, and 5-HT in the hippocampus, of BDNF(+/-) mice were significantly lower than those of wild-type mice. Interestingly, DR significantly increased the levels of 5-HT and 5-HIAA in the frontal cortex of BDNF(+/-) mice. These findings suggest that DR may alter the behaviours in BDNF(+/-) mice, and that the 5-HT system may be implicated in the beneficial effects of DR on these behaviours.
机译：越来越多的证据表明，脑源性神经营养因子（BDNF）在饮食行为中起作用，而BDNF-杂合（+/-）小鼠表现出异常行为（例如，肥胖，焦虑和攻击性）。进行本研究是为了确定饮食限制（DR）是否会改变BDNF（+/-）小鼠的行为，因为已经证明DR对大脑具有许多有益作用。将八周大的雄性野生型（+ / +）和BDNF（+/-）小鼠分为两组，随意饮食组和DR组，共16周。进行行为评估后，我们确定了BDNF mRNA水平以及亚型（5-HT（1A），5-HT（1B），5-HT（2A）和5-HT（2C）的mRNA水平。下丘脑，海马和额叶皮层中5-HT受体和5-HT转运蛋白（5-HTT）的水平，BDNF的蛋白质水平以及5-HT和5-HIAA的浓度。 DR显着改善了BDNF（+/-）小鼠的肥胖，焦虑和攻击性行为。 BDNF（+/-）小鼠的额叶皮层5-HT和5-HIAA含量以及海马区的5-HT浓度显着低于野生型小鼠。有趣的是，DR显着增加了BDNF（+/-）小鼠额叶皮层中5-HT和5-HIAA的水平。这些发现表明DR可能会改变BDNF（+/-）小鼠的行为，并且5-HT系统可能与DR对这些行为的有益作用有关。

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