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首页> 外文期刊>The European Journal of Neuroscience >Early life modulators and predictors of adult synaptic plasticity.
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Early life modulators and predictors of adult synaptic plasticity.

机译：成人突触可塑性的早期生命调节剂和预测因子。

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Early life experience can induce long-lasting changes in brain and behaviour that are opposite in direction, such as enhancement or impairment in regulation of stress response, structural and functional integrity of the hippocampus, and learning and memory. To explore how multiple early life events jointly determine developmental outcome, we investigated the combined effects of neonatal trauma (anoxia on postnatal day 1, P1) and neonatal novelty exposure (P2-21) on adult social recognition memory (3 months of age) and synaptic plasticity in the CA1 of the rat hippocampus (4.5-8 months of age). While neonatal anoxia selectively reduced post-tetanic potentiation (PTP), neonatal novel exposure selectively increased long-term potentiation (LTP). No interaction between anoxia and novelty exposure was found on either PTP or LTP. These findings suggest that the two contrasting neonatal events have selective and distinct effects on two different forms of synaptic plasticity. At the level of behaviour, the effect of novelty exposure on LTP was associated with increased social memory, and the effect of anoxia on PTP was not accompanied by changes in social memory. Such a finding suggests a bias toward the involvement of LTP over PTP in social memory. Finally, we report a surprising finding that an early behavioural measure of emotional response to a novel environment obtained at 25 days of age can predict adult LTP measured several months later. Therefore, individual differences in emotional responses present during the juvenile stage may contribute to adult individual differences in cellular mechanisms that underlie learning and memory.
机译：早期的生活经历会导致大脑和行为方向相反的长期变化，例如增强或减弱压力反应调节，海马结构和功能完整性以及学习和记忆的能力。为了探讨多个早期生活事件如何共同决定发育结果，我们调查了新生儿创伤（出生后第1天缺氧，P1）和新生儿新奇暴露（P2-21）对成人社交认可记忆（3个月大）的综合影响。大鼠海马（4.5-8个月大）CA1中的突触可塑性。虽然新生儿缺氧选择性降低了强直性强直（PTP），但新生儿新颖暴露选择性地增加了长期增强性（LTP）。在PTP或LTP上均未发现缺氧与新暴露之间的相互作用。这些发现表明，两个相反的新生儿事件对两种不同形式的突触可塑性具有选择性和独特的影响。在行为水平上，新事物暴露对LTP的影响与社交记忆的增加有关，而缺氧对PTP的影响与社交记忆的变化无关。这一发现表明，社会记忆中LTP优于PTP。最后，我们报告了一个令人惊讶的发现，即在25天龄时获得的对新环境的情感反应的早期行为测量可以预测数月后测量的成人LTP。因此，在青少年阶段出现的情绪反应中的个体差异可能会导致成人在学习和记忆基础上的细胞机制方面的个体差异。

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