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首页> 外文期刊>The European Journal of Neuroscience >Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
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Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.

机译：Lhx3是一种LIM域转录因子，在听觉中由Pou4f3调节，但在前庭系统中不受。

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摘要

A dominant mutation of the gene encoding the POU4F3 transcription factor underlies human non-syndromic progressive hearing loss DFNA15. Using oligonucleotide microarrays to generate expression profiles of inner ears of Pou4f3(ddl/ddl) mutant and wild-type mice, we have identified and validated Lhx3, a LIM domain transcription factor, as an in vivo target gene regulated by Pou4f3. Lhx3 is a hair cell-specific gene expressed in all hair cells of the auditory and vestibular system as early as embryonic day 16. The level of Lhx3 mRNA is greatly reduced in the inner ears of embryonic Pou4f3 mutant mice. Our data also show that the expression of Lhx3 is regulated differently in auditory and vestibular hair cells. This is the first example of a hair cell-specific gene expressed both in auditory and in vestibular hair cells, with differential regulation of expression in these two closely related systems.
机译：编码POU4F3转录因子的基因的显性突变是人类非综合征性进行性听力损失DFNA15的基础。使用寡核苷酸微阵列来生成Pou4f3（ddl / ddl）突变体和野生型小鼠的内耳表达谱，我们已经鉴定并验证了Lhx3，一种LIM域转录因子，是受Pou4f3调控的体内靶基因。 Lhx3是最早在胚胎第16天在听觉和前庭系统的所有毛细胞中表达的毛细胞特异性基因。在胚胎Pou4f3突变小鼠的内耳中，Lhx3 mRNA的水平大大降低。我们的数据还表明，Lhx3的表达在听觉和前庭毛细胞中受到不同的调节。这是在听觉和前庭毛细胞中表达的毛细胞特异性基因的第一个例子，在这两个密切相关的系统中表达的差异调节。

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