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首页> 外文期刊>The European Journal of Neuroscience >Daily torpor affects the molecular machinery of the circadian clock in Djungarian hamsters (Phodopus sungorus).
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Daily torpor affects the molecular machinery of the circadian clock in Djungarian hamsters (Phodopus sungorus).

机译：日常的折磨会影响Djungarian仓鼠（Phodopus sungorus）中昼夜节律的分子机制。

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摘要

Daily torpor in the Djungarian hamster (Phodopus sungorus) is a precisely timed event gated by the circadian clock situated in the suprachiasmatic nuclei (SCN) of the hypothalamus. Timing-controlled hypothermia during which body temperature (Tb) decreases to approximately 15 degrees C implies temperature compensation of the circadian system. Nevertheless, it remains controversial how the molecular clockwork functions at those low Tb values and whether the torpor bout affects the circadian system. In this study, we investigated rhythmic clock and clock-related gene as well as protein expression in the SCN and pineal gland of torpid and normothermic Djungarian hamsters over a 48 h cycle. We clearly demonstrate rhythmic gene expression of Per1, Bmal1 and Avp in the SCN as well as Aa-nat in the pineal gland on a day of torpor. Alterations in the phase and amplitude of these rhythms, however, may be due to decreased protein synthesis during hypothermia. This decreased protein feedback resulting from the hypothermia might also be responsible for changes in gene expression observed 1 day after a torpor bout. We conclude that temperature has at least a modulatory effect on the circadian system.
机译：Djungarian仓鼠（Phodopus sungorus）的日常折腾是一个精确定时的事件，该事件由位于下丘脑上视交叉核（SCN）的生物钟控制。体温（Tb）降低到大约15摄氏度的定时控制的低温意味着昼夜节律系统的温度补偿。然而，在这些低Tb值下分子发条如何发挥作用以及the回合是否影响昼夜节律系统仍存在争议。在这项研究中，我们调查了有节奏的时钟和与时钟相关的基因，以及在48小时的循环中，有毒的常温Djungarian仓鼠的SCN和松果体中的蛋白表达。我们清楚地证明了在一天的煎熬中，SCN中的Per1，Bmal1和Avp以及松果体中的Aa-nat的节律性基因表达。然而，这些节律的相位和振幅的改变可能是由于体温过低导致蛋白质合成减少。低温导致的蛋白质反馈降低可能也是造成玉米粥发作1天后基因表达变化的原因。我们得出结论，温度至少对昼夜节律系统具有调节作用。

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