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首页> 外文期刊>The European Journal of Neuroscience >The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D1-like, but not D2-like, dopamine receptors in the rat nucleus accumbens.
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The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D1-like, but not D2-like, dopamine receptors in the rat nucleus accumbens.

机译：I组代谢型谷氨酸受体拮抗剂S-4-CPG调节由伏伏性大鼠核中的D1样而不是D2样多巴胺受体活化而产生的运动反应。

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Functional interactions between dopamine (DA) and glutamate neurotransmissions in both the dorsal and the ventral striatum have been described for long time. However, there is much controversy as to whether glutamate transmission stimulates or attenuates DA release and locomotor activity. We investigated the functional interactions on locomotor activity between group I metabotropic glutamatergic receptors (mGlu receptors) and both D1-like and D2-like DA receptors in the rat nucleus accumbens. Intra-accumbens administration of the selective group I mGlu receptor antagonist S-4-CPG (0.2 or 2 microg per side), which had no effect when injected alone, prevented the increase in locomotor activity produced by the selective D1-like receptor agonist SKF 38393 (1 microg per side). Co-administration with S-4-CPG of the group I mGlu receptor agonist DHPG, but not of the group II mGlu receptor agonist APDC or the group III mGlu receptor agonist AP4, reversed the antagonistic effect of S-4-CPG on the SKF 38393-induced increase in locomotor activity. This indicates that the antagonistic effect of S-4-CPG could result from an action at the group I mGlu receptors. In contrast, administration of S-4-CPG showed no effect on the locomotor responses produced by either the selective D2-like receptor agonist LY 171555 (1 microg per side) or a mixed solution of SKF 38393 + LY 171555 (1 microg per side each). Altogether, these results confirm that glutamate transmission may control locomotor function through mGlu receptors in a DA-dependent manner, and further indicate that group I mGlu receptors would interact with D1-like receptors, but not D2-like receptors, to modulate DA transmission and locomotor activity.
机译：背侧和腹侧纹状体中多巴胺（DA）和谷氨酸神经传递之间的功能相互作用已被描述了很长时间。但是，关于谷氨酸的传递是刺激还是减弱DA的释放和运动活性存在很多争议。我们研究了大鼠伏伏核中I类代谢型谷氨酸能受体（mGlu受体）与D1样和D2样DA受体之间运动活动的功能性相互作用。选择性I组mGlu受体拮抗剂S-4-CPG（每侧0.2或2微克）的伏内注射给药（单药无效）阻止了选择性D1样受体激动剂SKF产生的运动活性增加38393（每侧1微克）。与第I组mGlu受体激动剂DHPG的S-4-CPG共同给药，但与第II组mGlu受体激动剂APDC或第III组mGlu受体激动剂AP4共同给药，却逆转了S-4-CPG对SKF的拮抗作用。 38393引起的运动活动增加。这表明S-4-CPG的拮抗作用可能是由对I类mGlu受体的作用引起的。相反，施用S-4-CPG对选择性D2类受体激动剂LY 171555（每侧1微克）或SKF 38393 + LY 171555（每侧1微克）的混合溶液产生的运动反应没有影响。每）。总而言之，这些结果证实谷氨酸传递可以以DA依赖性方式通过mGlu受体控制运动功能，并进一步表明I类mGlu受体将与D1样受体相互作用，但不与D2样受体相互作用，从而调节DA的传递。运动活动。

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