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首页> 外文期刊>The European Journal of Neuroscience >Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis.
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Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis.

机译:成年大鼠齿状回中的差异性神经发生:一个始终缺乏神经发生的可识别区域。

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摘要

The dentate gyrus continues to produce new neurons in adult rodents. The possibility of differential regulation of neurogenesis within regions of the dentate gyrus is largely unexplored, despite several other aspects of this phenomenon being well characterized in a large number of studies. In this report, we describe an area located at the anterior pole of the dentate gyrus that consistently lacks neurogenesis. This neurogenically quiescent zone invariably lacks expression of the neuroblast marker doublecortin (DCX), bromodeoxyuridine and Ki-67, though DCX expression can be elicited in response to a combined paradigm of environmental enrichment and wheel running. We propose that this region may provide a valuable model system to discern the factors that regulate the process of neurogenesis.
机译:齿状回继续在成年啮齿动物中产生新的神经元。尽管在许多研究中已经很好地描述了这种现象的其他几个方面,但在齿状回区域内神经发生的差异调节的可能性尚未得到充分的探讨。在本报告中,我们描述了位于齿状回前极的区域,该区域始终缺乏神经发生。这个神经源性的静止区总是缺少成神经细胞标志物双皮质素(DCX),溴脱氧尿苷和Ki-67的表达,尽管DCX的表达可以响应环境富集和车轮行驶的组合范例而引起。我们建议该区域可能提供有价值的模型系统,以识别调节神经发生过程的因素。

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