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首页> 外文期刊>The European Journal of Neuroscience >A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development.
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A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development.

机译：蜜蜂Dscam家族成员AbsCAM是具有神经突生长活性的大脑特异性细胞粘附分子，可影响发育过程中的神经元接线。

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摘要

The immunoglobulin superfamily (IgSF) has been indicated as functioning in the development and maintenance of nervous systems through cell-cell recognition and communication in several model invertebrates, Drosophila melanogaster and Caenorhabditis elegans. To further explore the functions of the IgSF in the brain of an invertebrate with more complex behavior, we identified and characterized a novel brain-specific Dscam family member, AbsCAM, from honey bee (Apis mellifera). The level of the AbsCAM protein was high in newly hatched bees and was dramatically reduced with age. The AbsCAM protein level was constant among worker bees of the same age performing different tasks, suggesting that it was primarily determined by age and not task in adult brains. Two different AbsCAM transcripts (AbsCAM-Ig7A and B) were generated by the alternative splicing of exon 11 encoding immunoglobulin domain 7 in an age-dependent manner. AbsCAM was expressed in the major brain neuropils where the synaptic density was high.AbsCAM can mediate the isoform-specific homophilic cell adhesion in vitro, and affected the axonal projections in Drosophila embryonic central nervous system and adult mushroom body by ectopic expression. Furthermore, AbsCAM promoted the neurite outgrowth of cultured neurons isolated from honey bee pupal brains. These results thus suggest that AbsCAM is the first honey bee IgSF implicated as functioning in neuronal wiring during honey bee brain development.
机译：免疫球蛋白超家族（IgSF）已被证明可通过多种模型无脊椎动物，果蝇和秀丽隐杆线虫中的细胞识别和交流，在神经系统的发育和维持中发挥作用。为了进一步探索IgSF在无脊椎动物行为复杂的大脑中的功能，我们鉴定了蜜蜂（Apis mellifera）的新型大脑特异性Dscam家庭成员AbsCAM并对其进行了表征。在刚孵化的蜜蜂中，AbsCAM蛋白的水平很高，并且随着年龄的增长而大大降低。在同一年龄的执行不同任务的工蜂中，AbsCAM蛋白水平恒定，这表明它主要由年龄决定，而不是在成年大脑中确定任务。通过以年龄依赖性方式交替编码编码免疫球蛋白结构域7的外显子11生成了两个不同的AbsCAM转录本（AbsCAM-Ig7A和B）。 AbsCAM在突触密度高的主要脑神经绒毛中表达，AbsCAM可以介导同工型特异的同源细胞粘附，并通过异位表达影响果蝇胚胎中枢神经系统和成年蘑菇体内的轴突投射。此外，AbsCAM促进了从蜜蜂p脑分离的培养神经元的神经突生长。因此，这些结果表明，AbsCAM是蜜蜂IgSF在蜜蜂大脑发育过程中在神经元接线中起作用的第一个因子。

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