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首页> 外文期刊>The European Journal of Neuroscience >Activation of phasic pontine-wave generator in the rat: a mechanism for expression of plasticity-related genes and proteins in the dorsal hippocampus and amygdala.
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Activation of phasic pontine-wave generator in the rat: a mechanism for expression of plasticity-related genes and proteins in the dorsal hippocampus and amygdala.

机译：大鼠相桥脑波发生器的激活：在海马背和杏仁核中表达可塑性相关基因和蛋白质的机制。

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A number of behavioral studies have emphasized the importance of interactions between the pontine-wave (P-wave) generator and the dorsal hippocampus (DH) in two-way active avoidance (TWAA) memory processing; however, the direct involvement of the P-wave generator in the TWAA training trial-induced molecular events in the DH and amygdala has not been systematically evaluated. Here we demonstrate that the TWAA learning training trials activate P-wave generator, and increase phosphorylation of CREB (pCREB) and expression of activity-regulated cytoskeletal-associated (Arc) protein, as well as messenger ribonucleic acid (mRNAs) of Arc, brain-derived nerve growth factor (BDNF) and early growth response-1 (Egr-1) in the DH and amygdala. Selective elimination of P-wave-generating cells abolished P-wave activity and suppressed TWAA learning training trial-induced expression of pCREB and Arc proteins and Arc, BDNF and Egr-1 mRNAs in the DH and amygdala. Following a session of TWAA training, all rats were equal in terms of time spent in wakefulness, slow-wave sleep and rapid eye movement (REM) sleep irrespective of P-wave lesions. The second set of experiments demonstrated that localized cholinergic stimulation of the P-wave generator increased expression of Arc, BDNF and Egr-1 mRNAs in the DH. Together, these findings provide the first direct evidence that activation of P-wave-generating cells is critically involved in the TWAA training trial-induced expression of plasticity-related genes in the DH and amygdala. These findings are discussed in relation to the role of P-wave generator activation for the REM sleep-dependent development and cognitive functions of the brain.
机译：大量的行为研究强调了在双向主动回避（TWAA）记忆处理中脑桥波（P波）发生器和海马背侧（DH）之间相互作用的重要性。但是，尚未对P波发生器直接参与TWAA训练试验诱发的DH和杏仁核分子事件的直接参与进行系统评估。在这里，我们证明TWAA学习训练试验激活了P波发生器，并增加了CREB（pCREB）的磷酸化和活性调节的细胞骨架相关（Arc）蛋白以及Arc，大脑的信使核糖核酸（mRNA）的表达DH和杏仁核中的神经源性神经生长因子（BDNF）和早期生长反应1（Egr-1）。选择性消除P波产生细胞消除了P波活性，并抑制了TWAA学习训练试验诱导的DH和杏仁核中pCREB和Arc蛋白以及Arc，BDNF和Egr-1 mRNA的表达。在进行TWAA训练后，所有大鼠在清醒，慢波睡眠和快速眼动（REM）睡眠上花费的时间均相等，而与P波损伤无关。第二组实验表明，P波发生器的局部胆碱能刺激增加了DH中Arc，BDNF和Egr-1 mRNA的表达。总之，这些发现提供了第一个直接的证据，即P波产生细胞的激活与TWAA训练试验诱导的DH和杏仁核中可塑性相关基因的表达密切相关。讨论了与P波发生器激活对REM睡眠相关的发育和大脑认知功能的作用有关的这些发现。

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