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首页> 外文期刊>The European Journal of Neuroscience >Rostrocaudal functional gradient among the pre-dorsal premotor cortex, dorsal premotor cortex and primary motor cortex in goal-directed motor behaviour
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Rostrocaudal functional gradient among the pre-dorsal premotor cortex, dorsal premotor cortex and primary motor cortex in goal-directed motor behaviour

机译：目标定向运动行为中前运动前皮层，背运动前皮层和初级运动皮层之间的杆状尾骨功能梯度

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The dorsal premotor cortex residing in the dorsolateral aspect of area 6 is a rostrocaudally elongated area that is rostral to the primary motor cortex (M1) and caudal to the prefrontal cortex. This region, which is subdivided into rostral [pre-dorsal premotor cortex (pre-PMd)] and caudal [dorsal premotor cortex proper (PMd)] components, probably plays a central role in planning and executing actions to achieve a behavioural goal. In the present study, we investigated the functional specializations of the pre-PMd, PMd, and M1, because the synthesis of the specific functions performed by each area is considered to be essential. Neurons were recorded while monkeys performed a conditional visuo-goal task designed to include separate processes for determining a behavioural goal (reaching towards a right or left potential target) on the basis of visual object instructions, specifying actions (direction of reaching) to be performed on the basis of the goal, and preparing and executing the action. Neurons in the pre-PMd and PMd retrieved and maintained behavioural goals without encoding the visual features of the visual object instructions, and subsequently specified the actions by multiplexing the goals with the locations of the targets. Furthermore, PMd and M1 neurons played a major role in representing the action during movement preparation and execution, whereas the contribution of the pre-PMd progressively decreased as the time of the actual execution of the movement approached. These findings revealed that the multiple processing stages necessary for the realization of an action to accomplish a goal were implemented in an area-specific manner across a functional gradient from the pre-PMd to M1 that included the PMd as an intermediary.
机译：位于区域6的背外侧的前运动背皮质是一个向后延伸的区域，该区域位于初级运动皮层（M1）的尾部，并且位于前额叶皮层的尾部。该区域可分为鼻状[前运动前皮层（pre-PMd）]和尾[运动前皮层（PMd）]组件，在计划和执行行动以实现行为目标方面可能起着核心作用。在本研究中，我们研究了PMd之前，PMd和M1之前的功能专业化，因为每个区域执行的特定功能的综合被认为是必不可少的。在猴子执行条件视听目标任务时记录神经元，该任务旨在包括根据视觉对象指令确定行为目标（达到左或右潜在目标）的单独过程，并指定要执行的动作（到达的方向）在目标的基础上，准备并执行操作。 PMd之前和PMd中的神经元在不编码视觉对象指令的视觉特征的情况下检索并维持了行为目标，随后通过将目标与目标的位置复用来指定动作。此外，PMd和M1神经元在代表运动准备和执行过程中的动作中起主要作用，而随着运动实际执行时间的临近，前PMd的贡献逐渐降低。这些发现表明，实现功能以实现目标所必需的多个处理阶段，是跨区域的，从前PMd到包含PMd作为中介的M1的功能梯度而实现的。

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