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首页> 外文期刊>The European Journal of Neuroscience >The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus
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The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus

机译：活性区蛋白CAST调节小鼠海马突触小泡的循环和数量大小

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摘要

Synaptic efficacy is determined by various factors, including the quantal size, which is dependent on the amount of neurotransmitters in synaptic vesicles at the presynaptic terminal. It is essential for stable synaptic transmission that the quantal size is kept within a constant range and that synaptic efficacy during and after repetitive synaptic activation is maintained by replenishing release sites with synaptic vesicles. However, the mechanisms for these fundamental properties have still been undetermined. We found that the active zone protein CAST (cytomatrix at the active zone structural protein) played pivotal roles in both presynaptic regulation of quantal size and recycling of endocytosed synaptic vesicles. In the CA1 region of hippocampal slices of the CAST knockout mice, miniature excitatory synaptic responses were increased in size, and synaptic depression after prolonged synaptic activation was larger, which was attributable to selective impairment of synaptic vesicle trafficking via the endosome in the presynaptic terminal likely mediated by Rab6. Therefore, CAST serves as a key molecule that regulates dynamics and neurotransmitter contents of synaptic vesicles in the excitatory presynaptic terminal in the central nervous system.
机译：突触功效取决于各种因素，包括数量大小，其大小取决于突触前末端突触小泡中神经递质的数量。对于稳定的突触传递至关重要的是，将量子大小保持在恒定范围内，并通过补充突触小泡的释放位点来维持反复突触激活期间和之后的突触功效。但是，这些基本属性的机制仍未确定。我们发现，活动区蛋白CAST（活动区结构蛋白处的细胞基质）在突触前定量大小和内吞突触小泡的循环利用中都起着关键作用。在CAST基因敲除小鼠的海马切片的CA1区中，微型兴奋性突触反应的大小增加，长时间的突触激活后突触抑制作用更大，这归因于突触囊泡通过突触前末端内体的选择性损伤。由Rab6介导。因此，CAST是调节中枢神经系统兴奋性突触前末端中突触小泡的动力学和神经递质含量的关键分子。

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