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首页> 外文期刊>The European Journal of Neuroscience >Direct current stimulation of prefrontal cortex modulates error-induced behavioral adjustments
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Direct current stimulation of prefrontal cortex modulates error-induced behavioral adjustments

机译：前额叶皮层的直流电刺激调节误差引起的行为调节

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摘要

Commission of errors and conflict between choices might induce behavioral modulations through adjustments in the executive control of behavior and altered patterns of these modulations are detected in neuropsychiatric disorders. We examined the effects of transcranial Direct Current Stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) on error- and conflict-induced behavioral modulations. Two separate cohorts of participants performed two clinically relevant tests of executive control, respectively. In the Wisconsin Card Sorting Test (WCST), the relevant rule for matching items frequently changed and therefore participants had to detect these unannounced changes by trial and error and alter their rule-based behavior. In the Stop task, participants had to rapidly respond to a directional go-signal but inhibit their responses when a stop signal appeared after the go-signal. Each participant received tDCS (sham, cathodal or anodal) in three separate sessions. Errors led to a slower response in the next trial (post-error slowing) in both tasks. The tDCS significantly modulated the post-error slowing in both tasks but did not affect the behavioral adjustments induced by the conflict. The modulation of post-error slowing by tDCS were polarity-dependent and also trial specific appearing immediately after errors. In the WCST and Stop task, the post-error slowing may reflect different processes involved in shifting the behavior-guiding rule and adjustments in inhibitory control of responses, respectively, and we found that the effective tDCS polarity differed between the two tasks. Here, we show that in two separate cognitive tasks direct current stimulation of DLPFC significantly modulated error-induced behavioral modulations.
机译：错误的选择和选择之间的冲突可能通过调节行为的执行控制来诱发行为调节，并且在神经精神疾病中检测到这些调节的改变模式。我们检查了经颅直流电刺激（tDCS）应用于背外侧前额叶皮层（DLPFC）对错误和冲突引起的行为调节的影响。两组独立的参与者分别进行了两项临床相关的执行控制测试。在威斯康星卡片分类测试（WCST）中，匹配项的相关规则经常更改，因此参与者必须通过反复试验来发现这些未宣布的更改，并更改其基于规则的行为。在“停止”任务中，参与者必须快速响应定向的go-signal，但在go-signal之后出现停止信号时抑制他们的响应。每个参与者在三个不同的环节中接受了tDCS（假，阴极或阳极）。错误导致这两个任务在下一个试验中的响应速度变慢（错误后速度变慢）。 tDCS显着调节了两项任务中的错误后速度，但并未影响冲突引起的行为调整。 tDCS对错误后减慢的调制是极性相关的，并且错误后立即出现特定于试验的内容。在WCST和Stop任务中，错误后的速度减慢可能分别反映了改变行为指导规则和对响应的抑制控制进行调整所涉及的不同过程，并且我们发现两个任务之间的有效tDCS极性不同。在这里，我们表明，在两个单独的认知任务中，DLPFC的直接电流刺激显着调节了误差引起的行为调制。

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