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首页> 外文期刊>The European Journal of Neuroscience >Neonatal functional blockade of the entorhinal cortex results in disruption of accumbal dopaminergic responses observed in latent inhibition paradigm in adult rats.
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Neonatal functional blockade of the entorhinal cortex results in disruption of accumbal dopaminergic responses observed in latent inhibition paradigm in adult rats.

机译：新生代内嗅皮层的功能性阻断导致成年大鼠潜在抑制范例中观察到的累积多巴胺能反应中断。

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摘要

Latent inhibition (LI) has been found to be disrupted in non-treated patients with schizophrenia. Dopaminergic (DAergic) dysfunctioning is generally acknowledged to occur in schizophrenia. Various abnormalities in the entorhinal cortex (ENT) have been described in patients with schizophrenia. Numerous data also suggest that schizophrenia has a neurodevelopmental origin. The present study was designed to test the hypothesis that reversible inactivation of the ENT during neonatal development results in disrupted DA responses characteristic of LI in adult rats. Tetrodotoxin (TTX) was microinjected locally in the left ENT at postnatal day 8 (PND8). DA variations were recorded in the dorsomedial shell and core parts of the nucleus accumbens (Nacc) using in vivo voltammetry in freely-moving grown-up rats in a LI paradigm. In the first session the animals were pre-exposed (PE) to the conditional stimulus (banana odour) alone. In the second they were aversively conditioned to banana odour. In the third (test) session the following results were obtained in PE animals subjected to temporary inactivation of the ENT at PND8: (1) aversive behaviour was observed in TTX-PE conditioned animals; (2) DA variations in the dorsomedial shell and core parts of the Nacc were similar in TTX-PE and non-pre-exposed conditioned rats. These findings strongly suggest that neonatal disconnection of the ENT disrupts LI in adult animals. They may further our understanding of the pathophysiology of schizophrenia.
机译：已发现在未治疗的精神分裂症患者中潜在抑制（LI）被破坏。多巴胺能（DAergic）功能障碍通常被认为发生在精神分裂症中。精神分裂症患者的内嗅皮层（ENT）出现了各种异常。大量数据还表明，精神分裂症具有神经发育起源。本研究旨在测试以下假说：在新生婴儿发育过程中，ENT的可逆失活导致成年大鼠LI的DA响应特性受到破坏。在出生后第8天（PND8），在左耳鼻喉科局部注射了河豚毒素（TTX）。使用体内伏安法在LI范例中自由移动的成年大鼠中，在伏隔核的背壳壳和核心部分（Nacc）中记录DA变化。在第一阶段中，仅对动物进行预条件（PE）的条件刺激（香蕉味）。第二，他们厌恶了香蕉气味。在第三（测试）阶段中，在PND8处使ENT暂时失活的PE动物中获得以下结果：（1）在TTX-PE适应动物中观察到厌恶行为; （2）在TTX-PE和未预先暴露的条件大鼠中，背囊外壳和Nacc核心部分的DA变化相似。这些发现强烈表明，新生儿耳鼻喉科的断开会破坏成年动物的LI。他们可能会进一步加深我们对精神分裂症病理生理的理解。

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