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首页> 外文期刊>The European Journal of Neuroscience >Detection psychophysics of intracortical microstimulation in rat primary somatosensory cortex.
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Detection psychophysics of intracortical microstimulation in rat primary somatosensory cortex.

机译：大鼠原代体感皮层皮质内微刺激的检测心理物理学。

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摘要

A problem of purposeful intracortical microstimulation is the long duration of neuronal integration time and the associated complex temporal interactions of effects to individual pulses in trains. Here we investigated the effects of repetitive stimuli on perception. We trained head-restraint rats to indicate the detection of cortical microstimulation in infragranular layers of barrel cortex. Three stimulus parameters: stimulus intensity, number of pulses and frequency were varied, and psychometric detection curves were assessed using the method of constant stimuli. The average psychophysical threshold of single pulses was 2.0 nC - a measure very close to what has been found earlier for the evocation of short-latency action potentials in neurons near the stimulation electrode. Detection of single-pulse stimulation always saturated at probabilities of about 0.8. In contrast, repetitive stimuli gave rise to lower thresholds (by a factor of two at 15 pulses, 320 Hz), and to saturation at probabilities close to 1. Interestingly, a large fraction of these perceptual benefits was observed already with double pulses. Moreover, the perceptual efficacy of individual pulses was higher using double pulses compared with longer sequences, i.e. double pulses were detected better than expected from the assumption of independence of single-pulse effects, while trains of 15 pulses fell well short of this expectation. The present results thus point to double-pulse stimulation as an optimal choice when trading economic stimulation against optimizing of the percept.
机译：有目的的皮层内微刺激的问题是神经元整合时间长且作用对列车中单个脉冲的相关复杂时间相互作用。在这里，我们研究了重复刺激对知觉的影响。我们训练了头枕型大鼠，以指示在桶状皮质下颗粒层中检测到皮质微刺激。改变三个刺激参数：刺激强度，脉冲数和频率，并使用恒定刺激方法评估心理检测曲线。单脉冲的平均心理物理阈值为2.0 nC-与早期在刺激电极附近的神经元中引起短潜伏期动作电位的方法非常接近。单脉冲刺激的检测总是以约0.8的概率饱和。相比之下，重复刺激会导致较低的阈值（在15个脉冲（320 Hz）时降低两倍），并且在概率接近1时达到饱和。有趣的是，在双脉冲中已经观察到了这些感知优势的很大一部分。此外，与更长的序列相比，使用双脉冲的单个脉冲的感知效率更高，即，从独立于单脉冲效应的假设出发，检测到的双脉冲比预期的要好，而15个脉冲的序列却远未达到此预期。因此，当前结果指出，在以经济刺激与最佳化进行交易时，双脉冲刺激是一种最佳选择。

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