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首页> 外文期刊>The European Journal of Neuroscience >Monocular deprivation reduces reliability of visual cortical responses to binocular disparity stimuli.
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Monocular deprivation reduces reliability of visual cortical responses to binocular disparity stimuli.

机译：单眼剥夺降低了视觉皮层对双眼视差刺激的反应的可靠性。

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While continuous monocular deprivation (MD) of patterned vision causes severe loss of visual cortical responses and visual acuity in the affected eye, these effects can be avoided by providing brief daily periods of binocular exposure [BE; D.E. Mitchell et al. (2003) Curr. Biol., 8, 1179-1182; D.E. Mitchell et al. (2006) Eur. J. Neurosci., 23, 2458-2466; D.S. Schwarzkopf et al. (2007) Eur. J. Neurosci., 25, 270-280]. In order to analyse binocular mechanisms involved in this phenomenon, we studied neuronal responses in primary visual cortex to binocular disparity stimuli in cats that had experienced mixed daily visual exposure (i.e. different amounts of daily binocular and monocular exposure). To examine whether binocular responses are as reliable in MD as in normal animals, we analysed single-trial responses to spatial phase disparity stimuli. In cats with various amounts of daily binocular experience (3.5 h, 7 h or 12 h) alone, about half of neurons (47.9%) showed reliable phase-specific binocular responses in two consecutive trials. The percentage of phase-selective cells was reduced in cats with mixed visual exposure with a decrease in the duration of daily BE. Within these neurons, a 'stable' cell population, i.e. with identical relative phases eliciting the strongest and weakest responses in two trials, was also reduced. In other words, the responses of neurons recorded from deprived animals were more likely to show different preferred phases on successive trials, although their amplitude ratios in both trials were about equal. We suggest that the detrimental effect of MD on binocular vision may begin, at least in part, with a subtle disruption of the mechanism involved in discrimination of binocular disparity signals.
机译：尽管连续的单眼剥夺（MD）会导致受影响的眼睛严重丧失视皮层反应和视敏度，但是可以通过每天短暂的双眼暴露来避免这些影响。 D.E. Mitchell等。 （2003）Curr。 ，8，1179-1182;和。 D.E. Mitchell等。 （2006）Eur。 J.Neurosci。，23，2458-2466; D.S. Schwarzkopf等。 （2007）Eur。 J. Neurosci。，25，270-280]。为了分析与这种现象有关的双眼机制，我们研究了日常混合视觉暴露（即每天不同数量的双眼和单眼暴露）的猫的初级视觉皮层对双眼视差刺激的神经元反应。为了检查双眼反应在MD中是否像正常动物一样可靠，我们分析了对空间相位差异刺激的单次试验反应。在每天有不同数量的双眼经验（3.5小时，7小时或12小时）的猫中，约有一半的神经元（47.9％）在两次连续试验中显示出可靠的阶段特异性双眼反应。混合视觉暴露的猫的相选择细胞百分比降低，每日BE持续时间减少。在这些神经元中，还减少了“稳定”的细胞群，即在两个试验中具有相同的相对相位引发最强和最弱反应的细胞群。换句话说，尽管两次试验中它们的振幅比大致相等，但在连续试验中，从被剥夺动物身上记录的神经元的反应更有可能显示出不同的优选阶段。我们建议，MD对双眼视力的有害影响可能至少部分地以对双眼视差信号的区分所涉及的机制的细微破坏开始。

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